US4314944A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Aminoalkyl-7-hydroxy-2(3H)-indolones
Assignee: SmithKline Beecham Corp
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Filing: 1980-08-22
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Granted: 1982-02-09
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Expires: 2000-08-22
Abstract
Abstract A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial activity on the cardiovascular system. A typical species of the group is 4-di-n-propylaminoethyl-7-hydroxy-2(3H)-indolone and its acid addition salts.
Inventors
- 👤 William F. Huffman
- 👤 James W. Wilson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:55
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/10; A; A61; A61P; A61P9/00; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/32; C07D209/34; C07D209/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
41 words
A compound of the structural formula: ##STR4## in which R is amino, lower alkylamino, di-loweralkylamino, di-N-allylamino or N-allyl-N-lower alkylamino, R 1 is hydroxy or methoxy and n is an integer from 1-3; together with the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
41 words
A compound of the structural formula: ##STR4## in which R is amino, lower alkylamino, di-loweralkylamino, di-N-allylamino or N-allyl-N-lower alkylamino, R 1 is hydroxy or methoxy and n is an integer from 1-3; together with the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1 in which R 1 is hydroxy.
Claim 4
Dependent Claim
18 words
The compound of claim 1 in which R 1 is hydroxy and R is di-n-propylamino, di-N-allylamino or N-allyl-N-propylamino.
Claim 5
Dependent Claim
11 words
The compound of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-7-hydroxy-2(3H)-indolone.
Claim 6
Dependent Claim
12 words
The compound of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-7-hydroxy-2(3H)-indolone hydrobromide.
Claim 7
Dependent Claim
14 words
The compound of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-7-hydroxy-2(3H)-indolone as the base.
Claim 8
Dependent Claim
19 words
The compound of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-7-methoxy-2(3H)-indolone together with its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
19 words
The compound of claim 1 in which the compound is 4-(2-di-N-allylaminoethyl)-7-hydroxy-2(3H)-indolone together with its pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
19 words
The compound of claim 1 in which the compound is 4-(2-aminoethyl)-7-hydroxy-2(3H)-indolone together with its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-08 | 1985-08-10 | 1986-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-08 | 1989-08-10 | 1990-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-08 | 1993-08-10 | 1994-02-09 | $7700.00 | Window Closed / Lapsed |