US4328245A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carbonate diester solutions of PGE-type compounds
Assignee: Syntex USA LLC
•
Filing: 1981-02-13
•
Granted: 1982-05-04
•
Expires: 2001-02-13
Abstract
Abstract Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.
Inventors
- 👤 Cheng-Der Yu
- 👤 Ursula Bruenner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61P; A61P43/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
42 words
A stable pharmaceutical composition comprising a PGE or PGE-type compound dissolved in a cyclic carbonate diester solvent which may contain water in an amount up to the solubility limit of water for the diester solvent encapsulated in a soft shelled gelatin capsule.
Claim 2
Dependent Claim
42 words
A stable pharmaceutical composition comprising a PGE or PGE-type compound dissolved in a cyclic carbonate diester solvent which may contain water in an amount up to the solubility limit of water for the diester solvent encapsulated in a soft shelled gelatin capsule.
Claim 3
Dependent Claim
25 words
A stable composition according to claim 1 wherein said compound is present in an amount between 0.001 mg to 100 mg per ml of solvent.
Claim 4
Dependent Claim
63 words
A stable composition according to claim 2 wherein said compound is selected from those represented by the formula: ##STR4## wherein: R is hydrogen, a lower alkyl group of 1 to 4 carbon atoms, or the pharmaceutically acceptable, non-toxic salts of compounds in which R is hydrogen; and X is hydrogen, o-, m- or p-halo, o, m- or p-methyl or o-, m- or p-methoxy.
Claim 5
Dependent Claim
29 words
A stable composition according to claim 3 wherein said compound is present in an amount between 0.01 mg to 20 mg per ml and said diester is propylene carbonate.
Claim 6
Dependent Claim
29 words
A stable composition according to claim 4 wherein the compound is (dl)-9-keto-11α,15α-dihydroxy-16-phenoxy-17,18,-19,20-tetranorprosta-4,5,13-trans-trienoic acid methyl ester and is present in an amount between 0.01 mg to 5 mg per ml.
Claim 7
Independent Claim
57 words
A method for preparing a stable soft-shelled gelatin capsule composition of PGE or PGE-type compounds which comprises dissolving at least one of said compounds in a cyclic carbonate diester solvent which may contain water in an amount up to the solubility limit of water in the diester solvent and adding the mixture to a soft-shelled gelatin capsule.
Claim 8
Independent Claim
57 words
A method for preparing a stable soft-shelled gelatin capsule composition of PGE or PGE-type compounds which comprises dissolving at least one of said compounds in a cyclic carbonate diester solvent which may contain water in an amount up to the solubility limit of water in the diester solvent and adding the mixture to a soft-shelled gelatin capsule.
Claim 9
Dependent Claim
22 words
The method of claim 6 wherein said compound is present in an amount between 0.001 mg to 100 mg per ml solvent.
Claim 10
Dependent Claim
61 words
The method of claim 7 wherein said compound is selected from those represented by the formula: ##STR5## wherein: R is hydrogen, a lower alkyl group of 1 to 4 carbon atoms, or the pharmaceutically acceptable, non-toxic salts of compounds in which R is hydrogen; and X is hydrogen, o-, m- or p-halo, o, m- or p-methyl or o-, m- or p-methoxy.
Claim 11
Dependent Claim
27 words
The method of claim 8 wherein said compound is present in an amount between 0.01 mg to 20 mg per ml; and said diester is propylene carbonate.
Claim 12
Dependent Claim
27 words
The method of claim 9 wherein the compound is (dl)-9-keto-11α,15α-dihydroxy-16-phenoxy-17,18,-19,20-tetranorprosta-4,5,13-trans-trienoic acid methyl ester and is present in an amount between 0.01 mg to 5 mg per ml.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-03 | 1985-11-02 | 1986-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-03 | 1989-11-02 | 1990-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-03 | 1993-11-02 | 1994-05-04 | $7700.00 | Window Closed / Lapsed |