US4329495A
Expired / Lapsed
US
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Enkephalinase enzyme inhibiting compounds
Assignee: Pfizer Inc
•
Filing: 1981-05-18
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Granted: 1982-05-11
•
Expires: 2001-05-18
Abstract
Abstract Chiral 2-(2-benzyl-3-mercaptopropionylamino)-1-alkanol derivatives and chiral 2-(2-benzyl-3-mercaptopropionylamino)-4-methylthiobutyric acids are inhibitors of enkephalinase enzyme, reflecting their clinical utility as analgesics or anticonvulsant agents, or as therapy for disorders in which endogenous enkephalin levels are below normal.
Inventors
- 👤 Jasjit S. Bindra
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:14
CPC Classifications
C; C07; C07C; C07C319/00; C07C319/14; C07C319/20; C07C59/00; C07C59/40; C07C59/58; C07C59/64; A; A61; A61P; A61P25/00; A61P25/04; C07C323/00; C07C323/50; C07C323/51; C07C323/60; C07C327/00; C07C57/00; C07C57/52; C07C57/58; C07C57/60
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
54 words
A compound of the formula ##STR9## wherein X is hydrogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, fluoro, chloro, bromo, or trifluoromethyl; R is hydrogen or (C 1 -C 3 )alkyl; n is 1 to 4, m is 0, 1 or 2; and R 1 is (C 1 -C 3 )alkyl.
Claim 2
Dependent Claim
54 words
A compound of the formula ##STR9## wherein X is hydrogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, fluoro, chloro, bromo, or trifluoromethyl; R is hydrogen or (C 1 -C 3 )alkyl; n is 1 to 4, m is 0, 1 or 2; and R 1 is (C 1 -C 3 )alkyl.
Claim 3
Dependent Claim
17 words
A compound of claim 1 wherein n is 2, m is 0 and R 1 is methyl.
Claim 4
Dependent Claim
9 words
A compound of claim 2 wherein R is hydrogen.
Claim 5
Dependent Claim
9 words
A compound of claim 3 wherein X is p-chloro.
Claim 6
Dependent Claim
9 words
A compound of claim 3 wherein X is p-methoxy.
Claim 7
Dependent Claim
9 words
A compound of claim 3 wherein X is hydrogen.
Claim 8
Dependent Claim
9 words
The compound of claim 6 of the formula (I).
Claim 9
Dependent Claim
9 words
The compound of claim 6 of the formula (II).
Claim 10
Dependent Claim
13 words
A compound of the formula ##STR10## or a pharmaceutically acceptable cationic salt thereof.
Claim 11
Dependent Claim
13 words
A compound of the formula ##STR10## or a pharmaceutically acceptable cationic salt thereof.
References Cited (Backward Citations)
US4046889A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-10 | 1985-11-09 | 1986-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-10 | 1989-11-09 | 1990-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-10 | 1993-11-09 | 1994-05-11 | $7700.00 | Window Closed / Lapsed |