US4335105A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Specific antigen vaccine for TGE in swine
Assignee: Iowa State University Research Foundation Inc
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Filing: 1981-05-11
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Granted: 1982-06-15
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Expires: 2001-05-11
Abstract
Abstract A vaccine for protecting swine against transmissible gastroenteritis (TGE) is prepared from a specific antigenic protein (SPA) obtained by separation from TGE virus. The SPA is characterized by a buoyant density of 1.02 to 1.03 gms/ml in a solution of sucrose. The vaccine may be prepared in parenteral dose form for administration to pregnant sows, thereby effectively protecting the baby pigs against fatal TGE infection.
Inventors
- 👤 Patricia M. Gough
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 22:49
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/215; A61K39/225; A61K2039/54; A61K2039/55; A61K2039/552; A61K2039/555; A61K2039/55505; A61K2039/55511; A61K2039/55566; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/20011; C12N2770/20034; Y; Y10; Y10S; Y10S424/00; Y10S424/815; Y10S530/00; Y10S530/82; Y10S530/826
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
92 words
A vaccine for protecting swine against transmissable gastroenteritis (TGE), wherein the vaccine is in an injectable dose form including an adjuvant and is characterized by containing a protection-effective amount of a specific antigenic protein (SPA) which has been separated from TGE virus, said SPA being soluble in water and having a buoyant density of 1.02 to 1.03 grams per milliliters (gms/ml) as determined in aqueous sucrose, and being further characterized by its lactogenic immunizing property of protecting the baby pig offspring against TGE infection when administered to a TGE non-immune pregnant sow.
Claim 2
Dependent Claim
92 words
A vaccine for protecting swine against transmissable gastroenteritis (TGE), wherein the vaccine is in an injectable dose form including an adjuvant and is characterized by containing a protection-effective amount of a specific antigenic protein (SPA) which has been separated from TGE virus, said SPA being soluble in water and having a buoyant density of 1.02 to 1.03 grams per milliliters (gms/ml) as determined in aqueous sucrose, and being further characterized by its lactogenic immunizing property of protecting the baby pig offspring against TGE infection when administered to a TGE non-immune pregnant sow.
Claim 3
Dependent Claim
38 words
The vaccine of claim 1 in which said SPA is further characterized by having charge-neutralized electrophoretic mobilities (Rf values) relative to human serum albumin of 1.84±0.01 in the presence of urea and 0.99±0.01 in the absence of urea.
Claim 4
Dependent Claim
20 words
The vaccine of claim 1 in which said SPA is further characterized by having an isoelectric point of pH 3.8.
Claim 5
Dependent Claim
21 words
The vaccine of claim 1 in which each dose of said vaccine contains from 0.5 to 3.0 mg of said SPA.
Claim 6
Dependent Claim
17 words
The vaccine of claim 1 or claim 4 in which said vaccine is free of TGE virus.
Claim 7
Dependent Claim
33 words
The vaccine of claims 1, 4 or 5 in which the TGE-derived protein in said vaccine is composed substantially entirely of said SPA together with another viral protein of the same buoyant density.
Claim 8
Dependent Claim
23 words
The vaccine of claims 1, 4 or 5 in which the TGE-derived protein in said vaccine is composed substantially entirely of said SPA.
Claim 9
Independent Claim
87 words
The method of protecting baby pig offspring against TGE infection, comprising administering a vaccine by injection to a TGE non-immune pregnant sow, said vaccine containing a swine immunizing specific antigenic protein (SPA) substantially free of transmissable gastroenteritis (TGE) virus and other TGE viral proteins characterized by being soluble in water and having a buoyant density of 1.02 to to 1.03 grams per milliliter (gms/ml) as determined in aqueous sucrose and being further characterized by its lactogenic immunizing property of protecting the baby pig offspring against TGE infection.
Claim 10
Independent Claim
87 words
The method of protecting baby pig offspring against TGE infection, comprising administering a vaccine by injection to a TGE non-immune pregnant sow, said vaccine containing a swine immunizing specific antigenic protein (SPA) substantially free of transmissable gastroenteritis (TGE) virus and other TGE viral proteins characterized by being soluble in water and having a buoyant density of 1.02 to to 1.03 grams per milliliter (gms/ml) as determined in aqueous sucrose and being further characterized by its lactogenic immunizing property of protecting the baby pig offspring against TGE infection.
Claim 11
Dependent Claim
38 words
The method of claim 8 in which said SPA is further characterized by having charge-neutralized electrophoretic mobilities (Rf values) relative to human serum albumin of 1.84±0.01 in the presence of urea and 0.99±0.01 in the absence of urea.
Claim 12
Dependent Claim
20 words
The method of claim 8 in which said SPA is further characterized by having an isoelectric point of pH 3.8.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |