US4344940A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Steroid formulation containing dipotassium EDTA
Assignee: ERSQUIBB & SONS Inc LAWRENCEVILLE-PRINCETON ROAD PRINCETON NJ 08540 A CORP OF DEL
•
Filing: 1981-11-30
•
Granted: 1982-08-17
•
Expires: 2001-11-30
Abstract
Abstract A steroid formulation is provided which is preferably in the form of a lotion or cream and contains a steroid, such as halcinonide, a polyol vehicle therefor, such as polyethylene glycol, and dipotassium ethylenediaminetetraacetic acid which is soluble in the polyol vehicle and inhibits metal catalyzed degradation of the steroid.
Inventors
- 👤 Wing-Sun Chow
- 👤 Donald C. Monkhouse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 22:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/16; A61K47/18; A61K47/183; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
27 words
A pharmaceutical composition comprising a steroid, a polyol vehicle in which said steroid is soluble, and potassium ethylenediaminetetraacetic acid to inhibit metal catalyzed degradation of said steroid.
Claim 2
Dependent Claim
27 words
A pharmaceutical composition comprising a steroid, a polyol vehicle in which said steroid is soluble, and potassium ethylenediaminetetraacetic acid to inhibit metal catalyzed degradation of said steroid.
Claim 3
Dependent Claim
16 words
The pharmaceutical composition as defined in claim 1 in the form of a lotion or cream.
Claim 4
Dependent Claim
50 words
The pharmaceutical composition as defined in claim 1 wherein the polyol is present in an amount within the range of from about 30 to about 95% by weight and the potassium ethylenediaminetetraacetic acid is present in an amount within the range of from about 0.001 to about 0.2% by weight.
Claim 5
Dependent Claim
14 words
The pharmaceutical composition as defined in claim 1 wherein said polyol is polyethylene glycol.
Claim 6
Dependent Claim
28 words
The pharmaceutical composition as defined in claim 4 wherein said polyethylene glycol has an average molecular weight of within the range of from about 200 to about 600.
Claim 7
Dependent Claim
20 words
The pharmaceutical composition as defined in claim 5 wherein said polyethylene glycol has an average molecular weight of about 300.
Claim 8
Dependent Claim
28 words
The pharmaceutical composition as defined in claim 5 wherein said polyethylene glycol is in the form of an aqueous solution containing at least 80% by weight polyethylene glycol.
Claim 9
Dependent Claim
31 words
The pharmaceutical composition as defined in claim 1 wherein said steroid is 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; 21-chloro-9-fluoro-2',3'-dihydro-11β-hydroxy-5'-phenylpregna-1,4-dieno[16α,17-b][1,4]dioxin-3,20-dione acetone solvate or dichloro methane solvate (1:1); progesterone; Δ'-testololactone; or 21-(acetyloxy)-9-fluoro-1',2',3',4'-tetrahydro-11β-hydroxypregna-1,4-dieno[16α,17-b]naphthalene-3,20-dione or (11β,16β)-9-fluoro-1',2',3',4'-tetrahydro-11,21-dihydroxypregna-1,4-dieno[16,17-b]-naphthalene-3,20-dione, hydrate 1:1.
Claim 10
Dependent Claim
13 words
The pharmaceutical composition as defined in claim 1 wherein said steroid is 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione.
Claim 11
Dependent Claim
60 words
The pharmaceutical composition as defined in claim 1 in the form of a lotion wherein said potassium ethylenediaminetetraacetic acid is present in an amount within the range of from about 0.001 to about 0.01% by weight and said polyol is polyethylene glycol and is present in an amount within the range of from about 50 to about 95% by weight.
Claim 12
Dependent Claim
13 words
The pharmaceutical composition as defined in claim 10 wherein said steroid is 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione.
Claim 13
Dependent Claim
39 words
The pharmaceutical composition as defined in claim 1 in the form of a lotion wherein said steroid is 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, and said polyol is 80 to 95% aqueous solution of polyethylene glycol having an average molecular weight of about 300.
Claim 14
Dependent Claim
58 words
The pharmaceutical composition as defined in claim 1 in the form of a cream wherein said potassium ethylenediaminetetraacetic acid is present in an amount within the range of from about 0.001 to about 0.2% by weight and said polyol is polyethylene glycol present in an amount within the range of from about 30 to about 70% by weight.
Claim 15
Dependent Claim
12 words
The pharmaceutical composition as defined in claim 1 further including a preservative.
Claim 16
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 1.
Claim 17
Dependent Claim
20 words
A method of treating dermatitis, which comprises adminsitering topically an effective amount of a composition as defined in claim 10.
Claim 18
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 11.
Claim 19
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 12.
References Cited (Backward Citations)
US3892857A
Cited
US3892856A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-16 | 1986-02-15 | 1986-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-16 | 1990-02-15 | 1990-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-16 | 1994-02-15 | 1994-08-17 | $7700.00 | Window Closed / Lapsed |