3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore

Claim 1

A compound selected from the group consisting of a compound defined by formula: ##STR4## wherein n is 0 to 4; p is 0 or 1; R and R 1 are independently H, lower alkyl, halogen, halogenated lower alkyl, nitro, or amino; X is oxygen, sulfur, sulfinyl, or sulfonyl; Y is imidazole, or lower alkyl and aryl derivatives of the foregoing, said aryl being a member selected from the group consisting of phenyl, halophenyl, and loweralkylphenyl; Z is a member selected from the group consisting of alkyl of 1 to 10 carbons, alkenyl of 3 to 10 carbons, alkynyl, of 3 to 10 carbons, cycloalkyl of 3 to 6 carbons, and heterocyclic aromatic groups selected from the group consisting of 2-thienyl, 3-thienyl, pyridyl, quinolyl, thiazolyl and furanyl, and the lower alkyl and halogen substituted derivatives thereof, provided that when n is 0, Z is not 1-alkynyl; and where n is 1 to 4, Z is also a member selected from the group consisting of phenyl, phenyl substituted by lower alkyl, halogen, or N-(N'-lower alkanoyl-piperazine), alkoxy of 1 to 10 carbons, alkylthio of 1 to 10 carbons, aryloxy, and arylthio, wherein said aryl moiety is a member selected from the group consisting of phenyl, halophenyl and lower alkyl phenyl; and the pharmaceutically acceptable acid addition salts thereof.