US4358434A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method, composition and kit for stabilizing radiolabeled compounds
Assignee: Revvity Health Sciences Inc
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Filing: 1979-12-19
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Granted: 1982-11-09
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Expires: 1999-12-19
Abstract
Abstract A method and kit for stabilizing solutions of radiolabelled compound by the use of insoluble quaternary ammonium containing compounds. Also described are novel insoluble compounds having quaternary ammonium and sulfide groups for use in the present invention.
Inventors
- 👤 Nathan R. Tzodikov
- 👤 Robert E. O'Brien
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:41
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/02; A61K51/04; A61K51/06; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/534; G01N33/58; G01N33/60; A61K2123/00
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
29 words
As an article of manufacture, a kit comprising at least one container of solution of a radiolabeled organic compound and a substantially insoluble resin containing a quaternary ammonium group.
Claim 2
Dependent Claim
29 words
As an article of manufacture, a kit comprising at least one container of solution of a radiolabeled organic compound and a substantially insoluble resin containing a quaternary ammonium group.
Claim 3
Dependent Claim
16 words
A kit as claimed in claim 1 wherein said radiolabeled compound is a radiolabeled amino acid.
Claim 4
Dependent Claim
16 words
A kit as claimed in claim 2 wherein said radiolabeled amino acid is methionine or leucine.
Claim 5
Dependent Claim
16 words
A kit as claimed in claim 1 wherein the quaternary ammonium is substituted by lower alkyl.
Claim 6
Dependent Claim
23 words
A kit comprising at least one container of solution of a radiolabeled compound and a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 7
Dependent Claim
23 words
A kit comprising at least one container of solution of a radiolabeled compound and a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 8
Dependent Claim
26 words
A kit as claimed in claim 1 wherein the counterion of said resin containing a quaternary ammonium group is halide or a lower alkyl carboxylate anion.
Claim 9
Dependent Claim
21 words
A kit as claimed in claim 1 wherein said resin containing a quaternary ammonium group, in addition, contains a sulfide group.
Claim 10
Dependent Claim
22 words
A kit comprising at least one container of solution of a radiolabeled compound and a substantially insoluble polystyrene divinyl benzene ammonium sulfide.
Claim 11
Dependent Claim
22 words
A kit comprising at least one container of solution of a radiolabeled compound and a substantially insoluble polystyrene divinyl benzene ammonium sulfide.
Claim 12
Dependent Claim
33 words
A kit as claimed in claim 1 wherein the solvent of said solution is water, ethanol, a mixture of water and ethanol, benzene, hexane, a dilute mineral acid, or a dilute organic acid.
Claim 13
Dependent Claim
23 words
A kit as claimed in claim 1 wherein the radionuclide of said radiolabeled compound is tritium, carbon-14, phosphorus-32, phosphorus-33, sulfur-35, iodine-125, or iodine-131.
Claim 14
Independent Claim
27 words
A method of stabilizing a solution of a radiolabeled organic compound comprising storing said solution in contact with a substantially insoluble resin containing a quaternary ammonium group.
Claim 15
Independent Claim
27 words
A method of stabilizing a solution of a radiolabeled organic compound comprising storing said solution in contact with a substantially insoluble resin containing a quaternary ammonium group.
Claim 16
Dependent Claim
16 words
A method as claimed in claim 11 wherein said radiolabeled compound is a radiolabeled amino acid.
Claim 17
Dependent Claim
14 words
A method as claimed in claim 12 wherein said radiolabeled amino acid is methionine.
Claim 18
Dependent Claim
16 words
A method as claimed in claim 11 wherein the quaternary ammonium is substituted by lower alkyl.
Claim 19
Independent Claim
26 words
A method of stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 20
Independent Claim
26 words
A method of stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 21
Dependent Claim
26 words
A method as claimed in claim 11 wherein the counterion of said resin containing a quaternary ammonium group is halide or a lower alkyl carboxylate anion.
Claim 22
Dependent Claim
21 words
A method as claimed in claim 11 wherein said resin containing a quaternary ammonium group, in addition, contains a sulfide group.
Claim 23
Independent Claim
25 words
A method of stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble polystyrene divinyl benzene ammonium sulfide.
Claim 24
Independent Claim
25 words
A method of stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble polystyrene divinyl benzene ammonium sulfide.
Claim 25
Dependent Claim
33 words
A method as claimed in claim 11 wherein the solvent of said solution is water, ethanol, a mixture of water and ethanol, benzene, hexane, a dilute mineral acid, or a dilute organic acid.
Claim 26
Dependent Claim
23 words
A method as claimed in claim 11 wherein the radionuclide of said radiolabeled compound is tritium, phosphorus-32, phosphorus-33, carbon-14, sulfur-35, iodine-125, or iodine-131.
Claim 27
Dependent Claim
24 words
A compound for stabilizing a solution of a radiolabeled organic compound comprising a substantially insoluble resinous substrate having pendant quaternary ammonium and sulfide groups.
Claim 28
Dependent Claim
24 words
A compound for stabilizing a solution of a radiolabeled organic compound comprising a substantially insoluble resinous substrate having pendant quaternary ammonium and sulfide groups.
Claim 29
Dependent Claim
30 words
A compound for stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble polystyrene-divinyl benzene copolymer, having pendant quaternary ammonium and sulfide groups.
Claim 30
Dependent Claim
30 words
A compound for stabilizing a solution of a radiolabeled compound comprising storing said solution in contact with a substantially insoluble polystyrene-divinyl benzene copolymer, having pendant quaternary ammonium and sulfide groups.
Claim 31
Dependent Claim
17 words
A compound as claimed in claim 21 wherein said quaternary ammonium group is substituted by lower alkyl.
Claim 32
Dependent Claim
18 words
A compound as claimed in claim 23 wherein said alkyl group contains from one to five carbon atoms.
Claim 33
Dependent Claim
24 words
A compound as claimed in claim 21 wherein the counterion of said quaternary ammonium group is a halide or a lower alkyl carboxylate anion.
Claim 34
Dependent Claim
12 words
A compound as claimed in claim 25 wherein said counterion is chloride.
Claim 35
Dependent Claim
16 words
A compound as claimed in claim 21 wherein said sulfide group is substituted by lower alkyl.
Claim 36
Dependent Claim
4 words
Polystyrene-divinylbenzene ammonium sulfide chloride.
Claim 37
Dependent Claim
4 words
Polystyrene-divinylbenzene ammonium sulfide chloride.
Claim 38
Dependent Claim
4 words
Polystyrene-divinylbenzene ammonium sulfide acetate.
Claim 39
Dependent Claim
4 words
Polystyrene-divinylbenzene ammonium sulfide acetate.
Claim 40
Dependent Claim
27 words
A method of making the compounds claimed in claim 21 comprising reacting an alkyl thiol and an trialkylamine with a substantially insoluble substrate having a reactive site.
Claim 41
Dependent Claim
26 words
A composition comprising a solution of a radiolabeled organic compound, said solution being maintained in contact with a substantially insoluble resin containing a quaternary ammonium group.
Claim 42
Dependent Claim
26 words
A composition comprising a solution of a radiolabeled organic compound, said solution being maintained in contact with a substantially insoluble resin containing a quaternary ammonium group.
Claim 43
Dependent Claim
16 words
A composition as claimed in claim 31 wherein said radiolabeled compound is a radiolabeled amino acid.
Claim 44
Dependent Claim
16 words
A composition as claimed in claim 32 wherein said radiolabeled amino acid is methionine or leucine.
Claim 45
Dependent Claim
17 words
A composition as claimed in claim 31 wherein the quaternary ammonium group is substituted by lower alkyl.
Claim 46
Dependent Claim
25 words
A composition comprising a solution of a radiolabeled compound, said solution being maintained in contact with a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 47
Dependent Claim
25 words
A composition comprising a solution of a radiolabeled compound, said solution being maintained in contact with a substantially insoluble quaternary ammonium substituted polystyrene-divinyl benzene copolymer.
Claim 48
Dependent Claim
26 words
A composition as claimed in claim 31 wherein the counterion of said resin containing a quaternary ammonium group is halide or a lower alkyl carboxylate anion.
Claim 49
Dependent Claim
21 words
A composition as claimed in claim 31 wherein said resin containing a quaternary ammonium group, in addition, contains a sulfide group.
Claim 50
Dependent Claim
25 words
A composition as claimed in claim 37 wherein said resin containing a quaternary ammonium and a sulfide group is a polystyrene divinyl benzene ammonium sulfide.
Claim 51
Dependent Claim
33 words
A composition as claimed in claim 31 wherein the solvent of said solution is water, ethanol, a mixture of water and ethanol, benzene, hexane, a dilute mineral acid, or a dilute organic acid.
Claim 52
Dependent Claim
23 words
A composition as claimed in claim 31 wherein the radionuclide of said radiolabeled compound is tritium, carbon-14, phosphorus-32, phosphorus-33, sulfur-35, iodine-125 or iodine-131.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-08 | 1986-05-10 | 1986-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-08 | 1990-05-10 | 1990-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-08 | 1994-05-10 | 1994-11-09 | $7700.00 | Window Closed / Lapsed |