US4358602A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ebelactones and production thereof
Assignee: Microbial Chemistry Research Foundation
•
Filing: 1981-03-04
•
Granted: 1982-11-09
•
Expires: 2001-03-04
Abstract
Abstract New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
Inventors
- 👤 Hamao Umezawa
- 👤 Takaaki Aoyagi
- 👤 Tomio Takeuchi
- 👤 Masa Hamada
- 👤 Shinichi Kondo
- 👤 Masaaki Ishizuka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 21:51
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C07; C07D; C07D305/00; C07D305/02; C07D305/10; C07D305/12; A; A61; A61P; A61P37/00; A61P37/02; A61P37/04; C12P; C12P17/00; C12P17/02; C12R; C12R2001/00; C12R2001/01; C12R2001/465
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
39 words
The new compound, ebelactone which is selected from ebelactone A and ebelactone B according to the general formula ##STR3## wherein R is methyl group --CH 3 for ebelactone A and ethyl group --CH 2 CH 3 for ebelactone B.
Claim 2
Dependent Claim
39 words
The new compound, ebelactone which is selected from ebelactone A and ebelactone B according to the general formula ##STR3## wherein R is methyl group --CH 3 for ebelactone A and ethyl group --CH 2 CH 3 for ebelactone B.
Claim 3
Dependent Claim
6 words
Ebelactone A of the formula ##STR4##
Claim 4
Dependent Claim
6 words
Ebelactone A of the formula ##STR4##
Claim 5
Dependent Claim
6 words
Ebelactone B of the formula ##STR5##
Claim 6
Dependent Claim
6 words
Ebelactone B of the formula ##STR5##
Claim 7
Dependent Claim
43 words
The process for the production of ebelactone, which comprises cultivating an ebelactone-producing strain of the genus Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone in the culture medium.
Claim 8
Dependent Claim
43 words
The process for the production of ebelactone, which comprises cultivating an ebelactone-producing strain of the genus Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone in the culture medium.
Claim 9
Dependent Claim
19 words
The process as claimed in claim 4 which comprises further a step of recovering ebelactone from the culture medium.
Claim 10
Dependent Claim
21 words
The process as claimed in claims 4 or 5 in which the ebelactone-producing strain is Streptomyces MG7-G1 identified as FERM-P 5363.
Claim 11
Dependent Claim
44 words
The process for the production of ebelactone A which comprises cultivating an ebelactone A-producing strain of Streptomyces under aerobic condtions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone A in the culture medium.
Claim 12
Dependent Claim
44 words
The process for the production of ebelactone A which comprises cultivating an ebelactone A-producing strain of Streptomyces under aerobic condtions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone A in the culture medium.
Claim 13
Dependent Claim
44 words
The process for the production of ebelactone B which comprises cultivating an ebelactone B-producing strain of Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone B in the culture medium.
Claim 14
Dependent Claim
44 words
The process for the production of ebelactone B which comprises cultivating an ebelactone B-producing strain of Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone B in the culture medium.
Claim 15
Dependent Claim
28 words
The process as claimed in claim 7 or 8 in which Streptomyces MG7-G1 is cultivated at a temperature of 20° to 37° C. for 1 to 3 days.
References Cited (Backward Citations)
US4242453A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-08 | 1986-05-10 | 1986-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-08 | 1990-05-10 | 1990-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-08 | 1994-05-10 | 1994-11-09 | $7700.00 | Window Closed / Lapsed |