US4370475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apramycin derivatives
Assignee: Shionogi and Co Ltd
•
Filing: 1981-10-22
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Granted: 1983-01-25
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Expires: 2001-10-22
Abstract
Abstract Novel 5,6-dideoxyapramycin derivatives having reinforced antimicrobial activity against gram-positive and negative bacteria with less side effects than apramycin, and produced by sulfonylation of 5- and 6-hydroxy groups and the subsequent reductive removal of sulfonates.
Inventors
- 👤 Kikuo Igarashi
- 👤 Tsunetoshi Honma
- 👤 Tamio Sugawara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:28
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/224; A; A61; A61P; A61P31/00; A61P31/04; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
91 words
An apramycin derivative of the formula ##STR6## wherein X represents hydrogen or an amino protecting group selected from the group consisting of C 2 -C 5 alkanoyl, C 2 -C 6 alkoxycarbonyl, C 7 -C 10 aroyl, C 6 -C 10 aryloxycarbonyl, C 7 -C 12 aralkoxycarbonyl, m-nitrophenylthio, and triphenylthio; Y represents hydrogen or a hydroxy protecting group selected from the group consisting of formyl, acetyl, benzoyl, benzyl, and tetrahydropyranyl; and the broken line represents the presence or absence of a double bond, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
91 words
An apramycin derivative of the formula ##STR6## wherein X represents hydrogen or an amino protecting group selected from the group consisting of C 2 -C 5 alkanoyl, C 2 -C 6 alkoxycarbonyl, C 7 -C 10 aroyl, C 6 -C 10 aryloxycarbonyl, C 7 -C 12 aralkoxycarbonyl, m-nitrophenylthio, and triphenylthio; Y represents hydrogen or a hydroxy protecting group selected from the group consisting of formyl, acetyl, benzoyl, benzyl, and tetrahydropyranyl; and the broken line represents the presence or absence of a double bond, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
14 words
An apramycin derivative claimed in claim 1, wherein the amino protecting group is benzyloxycarbonyl.
Claim 4
Dependent Claim
14 words
An apramycin derivative claimed in claim 1, wherein the hydroxy protecting group is acetyl.
Claim 5
Dependent Claim
1 words
5,6-Dideoxyapramycin.
Claim 6
Dependent Claim
1 words
5,6-Dideoxyapramycin.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-24 | 1986-07-26 | 1987-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-24 | 1990-07-26 | 1991-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-24 | 1994-07-26 | 1995-01-25 | $7700.00 | Window Closed / Lapsed |