US4384971A
Expired / Lapsed
US
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Cleansing composition for electronic particle counting apparatus; and method for its use
Assignee: Coulter Electronics Inc
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Filing: 1981-08-24
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Granted: 1983-05-24
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Expires: 2001-08-24
Abstract
Abstract An isotonic cleansing agent and method for its use in electronic instrumentation systems for determining hematological components of blood samples are described. The cleansing agent comprises an aqueous solution of a non-hemolytic polyoxyethylated alkylphenol detergent, dimethylolurea, and an isotonic and isoconductive saline base which is free of phosphates. The dimethylolurea serves as a cell stabilizer, and also acts as a germicidal agent, together with other added germicidal agents, particularly sodium 1-hydroxypyridine-2-thione.
Inventors
- 👤 II James H. Carter
- 👤 Harold R. Crews
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:32
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/48; C11D1/00; C11D1/66; C11D1/72; C11D3/16; C11D3/26; C11D3/32; C11D3/323
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
48 words
An isotonic cleansing agent for use in electronic instrumentation systems for determining hematological components of blood samples, comprising an aqueous solution of: a. A nonionic polyoxyethylated alkylphenol b. Dimethylolurea c. Sodium sulfate and sodium chloride, said cleansing agent being adjusted to 320±10 milliosmoles per kilogram with sodium chloride.
Claim 2
Dependent Claim
48 words
An isotonic cleansing agent for use in electronic instrumentation systems for determining hematological components of blood samples, comprising an aqueous solution of: a. A nonionic polyoxyethylated alkylphenol b. Dimethylolurea c. Sodium sulfate and sodium chloride, said cleansing agent being adjusted to 320±10 milliosmoles per kilogram with sodium chloride.
Claim 3
Dependent Claim
10 words
The isotonic cleansing agent of claim 1 including sodium 1-hydroxypyridine-2-thione.
Claim 4
Dependent Claim
9 words
The isotonic cleansing agent of claim 1 including 2-phenoxyethanol.
Claim 5
Dependent Claim
59 words
The isotonic cleansing agent of claim 1 wherein said nonionic polyoxyethylated alkylphenol has the following product specifications: ______________________________________
Appearance Clear, almost water-white liquid
1% solution Clear and colorless
Solubility in Water
Readily soluble, even in cold water
pH of 1% Solution
Neutral
Stability Stable to acids, alkalis and metallic ions
Cloud Point Clear at 212° F. (100° C.).
______________________________________
Claim 6
Dependent Claim
18 words
The isotonic cleansing agent of claim 1 wherein said dimethylolurea is present in a concentration from 0.5-2.0 g/L.
Claim 7
Independent Claim
48 words
A method for cleansing electronic instrumentation systems for determining hematological components of blood samples, comprising the use of an aqueous solution of: a. A nonionic polyoxyethylated alkylphenol b. Dimethylolurea c. Sodium sulfate and sodium chloride, said cleansing agent being adjusted to 320±10 milliosmoles per kilogram with sodium chloride.
Claim 8
Independent Claim
48 words
A method for cleansing electronic instrumentation systems for determining hematological components of blood samples, comprising the use of an aqueous solution of: a. A nonionic polyoxyethylated alkylphenol b. Dimethylolurea c. Sodium sulfate and sodium chloride, said cleansing agent being adjusted to 320±10 milliosmoles per kilogram with sodium chloride.
Claim 9
Dependent Claim
12 words
The method of claim 6 including sodium 1-hydroxypyridine-2-thione as an antibacterial agent.
Claim 10
Dependent Claim
37 words
The isotonic cleansing agent or method of claim 1 or 6 in which said sodium sulfate and sodium chloride are present in a concentration sufficient to form an isotonic and isoconductive saline base which is phosphate free.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-05-23 | 1986-11-22 | 1987-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-05-23 | 1990-11-22 | 1991-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-05-23 | 1994-11-22 | 1995-05-24 | $7700.00 | Window Closed / Lapsed |