US4405603A
Expired / Lapsed
US
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Method for rendering factors IX and X hepatitis-safe with calcium ions
Assignee: Centeon Pharma GmbH
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Filing: 1981-11-25
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Granted: 1983-09-20
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Expires: 2001-11-25
Abstract
Abstract What is disclosed is a method for making a preparation containing blood clotting Factors IX and/or X virtually hepatitis-safe by warming said peparation in the presence of calcium ions and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
Inventors
- 👤 Horst Schwinn
- 👤 Norbert Heimburger
- 👤 Gerhardt Kumpe
- 👤 Wilfried Wormsbacher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:37
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/647; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61L; A61L2/00; A61L2/02; A61L2/04; A61K38/00; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
70 words
A method for making a preparation containing at least one member selected from the group consisting of blood clotting Factor IX and blood clotting Factor X virtually hepatitis-safe, which method comprises warming said preparation in the presence of an effective amount of calcium ions and in the further presence of an effective amount of at least one member selected from the group consisting of amino acids, saccharides, and sugar alcohols.
Claim 2
Independent Claim
70 words
A method for making a preparation containing at least one member selected from the group consisting of blood clotting Factor IX and blood clotting Factor X virtually hepatitis-safe, which method comprises warming said preparation in the presence of an effective amount of calcium ions and in the further presence of an effective amount of at least one member selected from the group consisting of amino acids, saccharides, and sugar alcohols.
Claim 3
Dependent Claim
23 words
A method as in claim 1 wherein calcium ions are present in said preparation at a concentration from 0.05 mole/liter to 2.0 moles/liter.
Claim 4
Dependent Claim
81 words
A method as in claim 2 wherein said warming is at a temperature from 30° C. to 100° C. for 1 minute to 48 hours in the additional presence of 1.0 mole/liter to 3.0 moles/liter of at least one amino acid selected from the group consisting of glycine, α-alanine, β-alanine, hydroxyproline, proline, glutamine, and α-, β-, and γ-aminobutyric acids, and of 20 to 60 percent by weight of a member selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols.
References Cited (Backward Citations)
US4327086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |