US4424150A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acetaminophen analogs, antigens, and antibodies
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1982-04-02
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Granted: 1984-01-03
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Expires: 2002-04-02
Abstract
Abstract Carbonyl derivatives of acetaminophen are provided for use in homogeneous enzyme immunoassays for acetaminophen. The derivatives are conjugated to antigenic substances for the preparation of antisera specific to acetaminophen, and to enzymes for the preparation of enzyme conjugates which compete with acetaminophen for antibody binding sites in a typical assay.
Inventors
- 👤 Pyare Khanna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:07
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/535; G01N33/94; G01N33/9486; Y; Y10; Y10S; Y10S435/00; Y10S435/964
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
110 words
A compound of the formula ##STR3## wherein: X is methyl or --R--(CO) m Y is --R 1 --CO--NH--R 2 (CO) m when X is methyl, and hydrogen when X is --R--(CO) m R, R 1 , and R 2 are independently aliphatic linking groups of from 1 to 12 carbon atoms each; Z is a poly(amino acid) residue which is an antigen; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 2
Dependent Claim
110 words
A compound of the formula ##STR3## wherein: X is methyl or --R--(CO) m Y is --R 1 --CO--NH--R 2 (CO) m when X is methyl, and hydrogen when X is --R--(CO) m R, R 1 , and R 2 are independently aliphatic linking groups of from 1 to 12 carbon atoms each; Z is a poly(amino acid) residue which is an antigen; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 3
Dependent Claim
70 words
A compound of the formula: ##STR4## wherein: R is a aliphatic linking froup of from 1 to 12 carbon atoms; Z is m is zero or one when Z is a poly(amino acid) residue and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 4
Dependent Claim
70 words
A compound of the formula: ##STR4## wherein: R is a aliphatic linking froup of from 1 to 12 carbon atoms; Z is m is zero or one when Z is a poly(amino acid) residue and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 5
Dependent Claim
17 words
A compound according to claim 2 in which R is fully saturated and has a straight-chain configuration.
Claim 6
Dependent Claim
24 words
A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 2 to 8 carbon atoms.
Claim 7
Dependent Claim
24 words
A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 3 to 6 carbon atoms.
Claim 8
Dependent Claim
92 words
A compound of the formula: ##STR5## wherein: R 1 is an aliphatic linking group of from 1 to 12 carbon atoms; R 2 is an aliphatic linking group of from 1 to 12 carbon atoms; Z is a poly(amino acid) residue which is antigenic; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 9
Dependent Claim
92 words
A compound of the formula: ##STR5## wherein: R 1 is an aliphatic linking group of from 1 to 12 carbon atoms; R 2 is an aliphatic linking group of from 1 to 12 carbon atoms; Z is a poly(amino acid) residue which is antigenic; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 10
Dependent Claim
23 words
A compund according to claim 6 in which R 1 and R 2 are each fully saturated and each has a straight-chain configuration.
Claim 11
Dependent Claim
31 words
A compound according to claim 6 in which R 1 and R 2 are each fully saturated, each has a straight-chain configuration, and each contains from 1 to 6 carbon atoms.
Claim 12
Dependent Claim
43 words
A compound according to claim 6 in which R 1 and R 2 are each fully saturated and each has a straight-chain configuration, and R 1 contains from 1 to 4 carbon atoms, and R 2 contains from 1 to 3 carbon atoms.
Claim 13
Dependent Claim
42 words
A compound according to claims 1, 2, or 6 in which Z is a poly(amino acid) residue having a molecular weight of at least about 5000 daltons, and n ranges from one to approximately the molecular weight of Z divided by 1000.
Claim 14
Dependent Claim
43 words
A compound according to claim 1, 2, or 6 in which Z is a poly(amino acid) residue having a molecular weight from about 10,000 to about 1,000,000 daltons, and n ranges from one to approximately the molecular weight of Z divided by 3000.
Claim 15
Dependent Claim
35 words
A compound according to claims 1, 2, or 6 in which Z is an antigen having a molecular weight from about 10,000 to about 1,000,000 daltons, and n ranges from about 10 to about 100.
Claim 16
Dependent Claim
16 words
A compound according to claims 1, 2, or 6 in which Z is bovine serum albumin.
Claim 17
Dependent Claim
15 words
A compound according to claims 1, 2, or 6 in which Z is bovine gamma-globulin.
Claim 18
Dependent Claim
20 words
Antibodies prepared in response to a compound according to claims 1, 2, or 6 in which Z is an antigen.
Claim 19
Dependent Claim
33 words
Antibodies prepared in response to a compound according to claim 2 in which R is --CH 2 CH 2 CH 2 CH 2 -- and Z is bovine serum albumin or bovine gamma-globulin.
Claim 20
Dependent Claim
36 words
Antibodies prepared in response to a compound according to claim 6 in which R 1 is --CH 2 CH 2 --, R 2 is --CH 2 --, and Z is bovine serum albumin or bovine gamma-globulin.
References Cited (Backward Citations)
US3975342A
Cited
US3981863A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-02 | 1987-07-04 | 1988-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-02 | 1991-07-04 | 1992-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-02 | 1995-07-04 | 1996-01-03 | $7700.00 | Window Closed / Lapsed |