US4426383A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Theophylline and theobromine derivatives
Assignee: Eisai Co Ltd
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Filing: 1981-08-31
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Granted: 1984-01-17
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Expires: 2001-08-31
Abstract
Abstract A novel compound has the following formula: ##STR1## in which R 1 and R 2 are methyl or a group having the formula: ##STR2## provided that one of R 1 and R 2 is methyl and the other is said group, wherein R stands for a hydrogen atom or a lower alkyl group, Z stands for a group ##STR3## in which X 1 and X 2 , which may be the same or different, stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, or a pyridyl group or a group ##STR4## in which Y 1 and Y 2 , which may be the same or different stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, X stands for a nitrogen or carbon atom, and n is an integer of from 2 to 10, provided that when R 2 is the group having the formula II, X is not carbon and Z is not pyridyl.
Inventors
- 👤 Hachiro Sugimoto
- 👤 Takaharu Nakamura
- 👤 Sachiyuki Hamazo
- 👤 Toshiji Igarashi
- 👤 Yoshiharu Daiku
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:07
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/10; C07D473/08
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
59 words
A compound having the formula ##STR169## wherein Z is selected from the group consisting of (a) pyridyl and (b) ##STR170## in which Y 1 and Y 2 , which are the same or different, are hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen; and n is an integer of from 2 to 10; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
59 words
A compound having the formula ##STR169## wherein Z is selected from the group consisting of (a) pyridyl and (b) ##STR170## in which Y 1 and Y 2 , which are the same or different, are hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen; and n is an integer of from 2 to 10; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
A compound as claimed in claim 1 in which Z is pyridyl.
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 1 in which Z is ##STR171##
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 2 in which n is 3.
Claim 6
Dependent Claim
49 words
A compound having the formula ##STR172## wherein Z is ##STR173## in which Y 1 and Y 2 , which are the same or different, are hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen; and n is an integer of from 2 to 10; or a pharamceutically acceptable salt thereof.
Claim 7
Dependent Claim
49 words
A compound having the formula ##STR172## wherein Z is ##STR173## in which Y 1 and Y 2 , which are the same or different, are hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen; and n is an integer of from 2 to 10; or a pharamceutically acceptable salt thereof.
Claim 8
Dependent Claim
16 words
A compound as claimed in claim 5 in which n is 5 and Z is benzhydryl.
Claim 9
Dependent Claim
16 words
A compound as claimed in claim 5 in which n is 6 and Z is ##STR174##
Claim 10
Dependent Claim
27 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound as defined in claim 1, for vasodilating purposes, in combination with a pharmacologically acceptable carrier.
Claim 11
Dependent Claim
27 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound as defined in claim 1, for analgesic purposes, in combination with a pharmacologically acceptable carrier.
Claim 12
Dependent Claim
25 words
A method for treating a subject suffering from blood circulatory insufficiency which comprises administering to the subject a pharmaceutical composition as defined in claim 8.
Claim 13
Dependent Claim
24 words
A method for treating a subject suffering from a pain which comprises administering to the subject a pharmaceutical composition as defined in claim 9.
Claim 14
Dependent Claim
27 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound as defined in claim 8, for vasodilating purposes, in combination with a pharmacologically acceptable carrier.
Claim 15
Dependent Claim
27 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound as defined in claim 8, for analgesic purposes, in combination with a pharmacologically acceptable carrier.
Claim 16
Dependent Claim
25 words
A method for treating a subject suffering from blood circulatory insufficiency which comprises administering to the subject a pharmaceutical composition as defined in claim 12.
Claim 17
Dependent Claim
24 words
A method for treating a subject suffering from a pain which comprises administering to the subject a pharmaceutical composition as defined in claim 13.
References Cited (Backward Citations)
US3459753A
Cited
US4284633A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-16 | 1987-07-18 | 1988-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-16 | 1991-07-18 | 1992-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-16 | 1995-07-18 | 1996-01-17 | $7700.00 | Window Closed / Lapsed |