US4434095A
Expired / Lapsed
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Cyclic analogue of naturally-occurring phagocytosis-stimulant peptide - threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl]
Assignee: INSTITUT ORGANICHESKOGO SINTEZA USSR RIGA
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Filing: 1980-04-02
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Granted: 1984-02-28
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Expires: 2000-04-02
Abstract
Abstract A novel substance, that is a cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide - threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] of the formula: ##STR1## A method for preparing threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] by way of a step-wise building-up of the peptide chain from the C-terminal by means of activated ethers of benzyloxycarbonyl-proline, tert.butyloxycarbonyl- -N.sup.ε -benzyl-oxycarbonyl-lysine and tert.butyloxycarbonyl-threonine, followed by cyclization of the resulting partly blocked tetrapeptide using Woodward reagent in an excess of dimethylformamide and isolation of the desired product.
Inventors
- 👤 Gunar I. Chipens
- 👤 Nadezhda I. Veretennikova
- 👤 Zeltite A. Atare
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:02
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0215; A; A61; A61P; A61P37/00; A61P37/02; A61P37/04; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1013; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/27
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
13 words
A cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide--threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] of the formula: ##STR6##
Claim 2
Dependent Claim
13 words
A cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide--threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] of the formula: ##STR6##
Claim 3
Dependent Claim
65 words
A method for preparing threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] according to claim 1, wherein the synthesis of threonyl-cyclo-[-N.sup.ε -lysyl-prolyl-arginyl-] is effected by way of a step-wise building-up of the peptide chain from the C-terminal using activated ethers of benzyloxycarbonyl-proline, tert.butyloxycarbonyl-N.sup.ε -benzyloxycarbonyl-lysine and tert.butyloxycarbonyyl-threonine, followed by cyclization of the resulting partly blocked tetrapeptide by means of Woodward reagent in an excess of dimethylformamide and isolation of the desired product.
References Cited (Backward Citations)
US3778426A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-27 | 1987-08-29 | 1988-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-27 | 1991-08-29 | 1992-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-27 | 1995-08-29 | 1996-02-28 | $7700.00 | Window Closed / Lapsed |