US4438115A
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US
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Compositions and methods for treating diseases in circulatory organs
Assignee: Chugai Pharmaceutical Co Ltd
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Filing: 1981-06-10
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Granted: 1984-03-20
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Expires: 2001-06-10
Abstract
Abstract An agent for treating diseases in circulatory organs which comprises a piperazine compound of the formula ##STR1## wherein R 1 , R 2 and A are as defined hereunder, or a salt thereof and a pharmaceutically acceptable carrier.
Inventors
- 👤 Hiroyuki Nagano
- 👤 Mitiro Takagi
- 👤 Noboru Kubodera
- 👤 Isao Matsunaga
- 👤 Tamotsu Yamazaki
- 👤 Hiroyuki Nabata
- 👤 Kazushige Sakai
- 👤 Shun-ichi Hata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:45
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/02; C07D295/04; C07D295/14; C07D295/145; C07D295/15; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61P; A61P9/00; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
71 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR8## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier selected from the group consisting of lactose, starch, mannitol, sucrose, kaolin, crystalline cellulose, talc, calcium carbonate and magnesium stearate.
Claim 2
Dependent Claim
71 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR8## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier selected from the group consisting of lactose, starch, mannitol, sucrose, kaolin, crystalline cellulose, talc, calcium carbonate and magnesium stearate.
Claim 3
Dependent Claim
74 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR9## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier, wherein said composition is formulated into the form of a tablet, granule, powder, capsule or slow release agent for oral administration.
Claim 4
Dependent Claim
74 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR9## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier, wherein said composition is formulated into the form of a tablet, granule, powder, capsule or slow release agent for oral administration.
Claim 5
Dependent Claim
26 words
A composition according to claim 2 in unit dosage form, containing 0.5 to 60 mg of the piperazine compound or a salt thereof per unit dosage.
Claim 6
Dependent Claim
70 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR10## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier, wherein said composition is formulated into the form of an injection and wherein said carrier is mannitol.
Claim 7
Dependent Claim
70 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR10## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof and a pharmaceutically acceptable carrier, wherein said composition is formulated into the form of an injection and wherein said carrier is mannitol.
Claim 8
Dependent Claim
26 words
A composition according to claim 4 in unit dosage form, containing 0.1 to 10 mg of the piperazine compound or a salt thereof per unit dosage.
Claim 9
Independent Claim
60 words
A method for treating diseases in circulatory organs which comprises administering to a patient having such a disease an effective amount of a piperazine compound of the formula: ##STR11## wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof.
Claim 10
Independent Claim
60 words
A method for treating diseases in circulatory organs which comprises administering to a patient having such a disease an effective amount of a piperazine compound of the formula: ##STR11## wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight or branched alkylene) or a salt thereof.
Claim 11
Dependent Claim
12 words
A method in accordance with claim 6 wherein such disease is hypertension.
Claim 12
Dependent Claim
14 words
A method in accordance with claim 6 wherein such disease is ischemic cardiac disease.
Claim 13
Dependent Claim
21 words
A method in accordance with claim 6 wherein such disease is one treatable by an agent for vasodilating peripheral blood vessels.
Claim 14
Dependent Claim
23 words
A method in accordance with claim 6 wherein said piperazine is administered in an effective dosage of 0.1 to 1000 mg per day.
Claim 15
Dependent Claim
23 words
A method in accordance with claim 6 wherein said piperazine is administered in an effective dosage of 1 to 50 mg per day.
Claim 16
Dependent Claim
57 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR12## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight-chain or branched alkylene having 4-12 carbon atoms) or a salt thereof and a pharmaceutically acceptable carrier.
Claim 17
Dependent Claim
57 words
A composition for treating diseases in circulatory organs which comprises a piperazine compound of the formula: ##STR12## (wherein R 1 is a lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; and A is a straight-chain or branched alkylene having 4-12 carbon atoms) or a salt thereof and a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
42 words
A composition in accordance with claim 12 wherein R 1 is an alkyl group having 1-4 carbon atoms, R 2 is hydrogen or an alkyl group having 1-4 carbon atoms and A is a straight-chain or branched alkylene having 4-10 carbon atoms.
Claim 19
Dependent Claim
29 words
A method for treating diseases in circulatory organs which comprises administering to a patient having such a disease an effective amount of the composition in accordance with claim 12.
Claim 20
Dependent Claim
29 words
A method for treating diseases in circulatory organs which comprises administering to a patient having such a disease an effective amount of the composition in accordance with claim 13.
References Cited (Backward Citations)
US2922788A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |