US4438239A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microsphere coated substrate containing reactive aldehyde groups
Assignee: California Institute of Technology
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Filing: 1981-03-30
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Granted: 1984-03-20
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Expires: 2001-03-30
Abstract
Abstract A synthetic organic resin is coated with a continuous layer of contiguous, tangential, individual microspheres having a uniform diameter preferably between 100 Angstroms and 2000 Angstroms. The microspheres are an addition polymerized polymer of an unsaturated aldehyde containing 4 to 20 carbon atoms and are covalently bonded to the substrate by means of high energy radiation grafting. The microspheres contain reactive aldehyde groups and can form conjugates with proteins such as enzymes or other aldehyde reactive materials.
Inventors
- 👤 Alan Rembaum
- 👤 Richard C. K. Yen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:30
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/545; G01N33/54313; G01N33/54326; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/25; Y10T428/254; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
92 words
A coated article comprising: a synthetic organic resin substrate, said resin being capable of developing covalent bonds during high energy radiation; a continuous layer of contiguous, tangential, individual microspheres having an uniform diameter between 100 Angstroms and 2000 Angstroms bound to the surface of the substrate by covalent bonds formed between the resin and the microspheres by means of high energy radiation grafting of the microspheres to the surface of the resin substrate, said microspheres consisting essentially of the addition polymerized polymer of an unsaturated aldehyde containing 4 to 20 carbon atoms.
Claim 2
Dependent Claim
92 words
A coated article comprising: a synthetic organic resin substrate, said resin being capable of developing covalent bonds during high energy radiation; a continuous layer of contiguous, tangential, individual microspheres having an uniform diameter between 100 Angstroms and 2000 Angstroms bound to the surface of the substrate by covalent bonds formed between the resin and the microspheres by means of high energy radiation grafting of the microspheres to the surface of the resin substrate, said microspheres consisting essentially of the addition polymerized polymer of an unsaturated aldehyde containing 4 to 20 carbon atoms.
Claim 3
Dependent Claim
21 words
A coated article according to claim 1 in which the resin is selected from polyethylene, polypropylene, polystyrene, acrylic polymers or dextran.
Claim 4
Dependent Claim
33 words
A coated article according to claim 1 in which the polymer further consists essentially of at least 20% of an addition polymerizable comonomer having a hydrophilic substituent selected from hydroxyl, amino or carboxyl.
Claim 5
Dependent Claim
20 words
A coated article according to claim 1 in which the substrate is at least 10 times larger than the microspheres.
Claim 6
Dependent Claim
21 words
A coated article according to claim 4 in which the thickness of the layer is from 100 Angstroms to 1000 microns.
Claim 7
Dependent Claim
21 words
An article according to claim 4 in which the substrate is in the form of spheres, particles, sheets, rods or tubes.
Claim 8
Dependent Claim
26 words
An article according to claim 6 in which the aldehyde is selected from acrolein and C 1 to C 8 alkyl, aryl and cycloalkyl derivatives thereof.
Claim 9
Dependent Claim
23 words
A composition comprising an adduct of the article of claim 1 with a material selected from aldehyde reactive proteins, pharmaceuticals and fluorescent chromophores.
Claim 10
Dependent Claim
12 words
A composition according to claim 8 in which the aldehyde is acrolein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |