US4448781A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-Benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme
Assignee: Pfizer Inc
•
Filing: 1981-07-27
•
Granted: 1984-05-15
•
Expires: 2001-07-27
Abstract
Abstract The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.
Inventors
- 👤 Peter E. Cross
- 👤 Roger P. Dickinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:38
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/56; C07D233/60; A; A61; A61P; A61P25/00; A61P25/04; A61P25/06; A61P3/00; A61P3/08; A61P3/10; A61P43/00; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/08; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
57 words
A compound of the formula ##STR5## or a pharmaceutically acceptable acid addition salt thereof, wherein: R 1 is hydrogen, C 1 -C 4 lower alkyl, C 1 -C 4 lower alkoxy or halogen; and Y is (CH 2 ) n where n is an integer of from 1 to 4, or a group of the formula ##STR6##
Claim 2
Dependent Claim
57 words
A compound of the formula ##STR5## or a pharmaceutically acceptable acid addition salt thereof, wherein: R 1 is hydrogen, C 1 -C 4 lower alkyl, C 1 -C 4 lower alkoxy or halogen; and Y is (CH 2 ) n where n is an integer of from 1 to 4, or a group of the formula ##STR6##
Claim 3
Dependent Claim
12 words
A compound of claim 1 wherein R 1 is hydrogen or methyl.
Claim 4
Dependent Claim
11 words
A compound of claim 1 or 2 wherein Y is methylene.
Claim 5
Dependent Claim
11 words
A compound of claim 1 or 2 wherein Y is benzyl.
Claim 6
Dependent Claim
34 words
A pharmaceutical composition for use as a selective inhibitor of thromboxane synthetase enzyme comprising a thromboxane synthetase enzyme inhibiting amount of a compound of claim 1 together with a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
40 words
A method of selectively inhibiting the action of the thromboxane synthetase enzyme in an animal which comprises administering to the animal a thromboxane synthetase inhibiting amount of a compound of claim 1 or of a pharmaceutical composition of claim 5.
References Cited (Backward Citations)
CH271776A
Cited
US3498999A
Cited
GB1510016A
Cited
US4118487A
Cited
US4183742A
Cited
GB2031408A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-15 | 1987-11-14 | 1988-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-15 | 1991-11-14 | 1992-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-15 | 1995-11-14 | 1996-05-15 | $7700.00 | Window Closed / Lapsed |