US4452862A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical coating materials soluble or swellable in gastric juice and pharmaceutical dosage forms coated therewith
Assignee: Roehm GmbH Darmstadt
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Filing: 1982-02-03
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Granted: 1984-06-05
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Expires: 2002-02-03
Abstract
Abstract Coating materials for pharmaceutical dosage forms contain, besides the conventional liquid or solid additives for pharmaceutical coatings, a binder comprising a synthetic polymer, prepared by emulsion polymerization, having 5 to 100% by weight of units derived from monomers of the formula ##STR1## wherein R 1 is a hydrogen atom or a lower alkyl group, R 2 is an alkylene or aralkylene group having at least 3 carbon atoms in the chain between the amino nitrogen and the ester oxygen atom of which at least one is tertiary or quaternary, and R 3 and R 4 are lower alkyl radicals or together with the amino-nitrogen atom form a heteroaliphatic ring, and, optionally, additional comonomer units.
Inventors
- 👤 Gerhard Markert
- 👤 Dieter Dreher
- 👤 Klaus Lehmann
- 👤 Werner Siol
- 👤 Hubert Rauch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/284; A61K9/2846; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
95 words
A pharmaceutical dosage form coated with a synthetic polymer, soluble or swellable in gastric juice, prepared by emulsion polymerization comprising (1) 5-100% by weight of units derived from an aminoalkyl ester monomer of the formula ##STR3## wherein: R 1 =hydrogen or a lower alkyl group, R 2 =2,2-dimethyl propyl or benzyl, R 3 and R 4 =lower alkyl groups or together with the N atom form a penta or hexa atomic heterocyclic ring; and (2) 0-80% by weight of a copolymerizable monomer selected from the group consisting of esters of acrylic acid and methacrylic acid.
Claim 2
Dependent Claim
95 words
A pharmaceutical dosage form coated with a synthetic polymer, soluble or swellable in gastric juice, prepared by emulsion polymerization comprising (1) 5-100% by weight of units derived from an aminoalkyl ester monomer of the formula ##STR3## wherein: R 1 =hydrogen or a lower alkyl group, R 2 =2,2-dimethyl propyl or benzyl, R 3 and R 4 =lower alkyl groups or together with the N atom form a penta or hexa atomic heterocyclic ring; and (2) 0-80% by weight of a copolymerizable monomer selected from the group consisting of esters of acrylic acid and methacrylic acid.
Claim 3
Dependent Claim
14 words
The dosage form of claim 1 wherein R 1 is a lower alkyl group.
Claim 4
Dependent Claim
13 words
The dosage form of claim 1 wherein said aminoalkyl ester is N,N-dimethylamino-2,2-dimethylpropyl methacrylate.
Claim 5
Dependent Claim
19 words
The dosage form of claim 1 wherein residues of said aminoalkyl ester constitute 10-90% by weight of said polymer.
Claim 6
Dependent Claim
57 words
A synthetic dosage form with a coating comprising (a) 25-100% by weight of the polymer of any one of claims 1,2 or 3 and (b) 0-25% by weight of a pharmaceutically acceptable non-toxic coating additive selected from the group consisting of pigments, fillers, dyes, plasticizers, gloss improvers, smoothing agents, flavors, photostabilizers, anti-foaming agents, and flow improving materials.
Claim 7
Dependent Claim
18 words
The dosage form of claim 1 wherein said dosage form is a dosage form suitable for oral administration.
Claim 8
Dependent Claim
24 words
The dosage form of claim 1 wherein said dosage form is selected from the group consisting of crystals, granules, pills dragees, tablets, and capsules.
References Cited (Backward Citations)
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Cited
US4180519A
Cited
US4036768A
Cited
US4234565A
Cited
US4297185A
Cited
US4325862A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-05 | 1987-12-05 | 1988-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-05 | 1991-12-05 | 1992-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-05 | 1995-12-05 | 1996-06-05 | $7700.00 | Window Closed / Lapsed |