US4454119A
Expired / Lapsed
US
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Therapeutic agents
Assignee: Mitsubishi Chemical Corp
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Filing: 1981-06-29
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Granted: 1984-06-12
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Expires: 2001-06-29
Abstract
Abstract A therapeutic agent comprising an oil-in-water type suspension of an alkali treated lipopolysaccharide from gram negative bacteria and cord factor of acid fast bacteria or its similar substance of corynebacteria.
Inventors
- 👤 Kazue Fukushi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:15
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/66; A61K35/74; A61K31/00; A61K31/70; A61K31/715; C; C12; C12P; C12P19/00; C12P19/12
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
44 words
A therapeutic agent comprising an oil-in-water suspension of (A) an alkali treated lipopolysaccharide from gram negative bacteria and (B) a cord factor of acid fast bacteria or its similar substance of corynebacteria, the proportions of (A) to (B) being 20:1 to 1:2 by weight.
Claim 2
Dependent Claim
44 words
A therapeutic agent comprising an oil-in-water suspension of (A) an alkali treated lipopolysaccharide from gram negative bacteria and (B) a cord factor of acid fast bacteria or its similar substance of corynebacteria, the proportions of (A) to (B) being 20:1 to 1:2 by weight.
Claim 3
Dependent Claim
16 words
The therapeutic agent of claim 1, wherein the gram negative bacteria are gram negative rods bacteria.
Claim 4
Dependent Claim
13 words
The therapeutic agent of claim 2, wherein the gram negative bacteria are Salmonella.
Claim 5
Dependent Claim
17 words
The therapeutic agent of claim 3, wherein the gram negative bacteria are Salmonella minnesota or Salmonella typhimurium.
Claim 6
Dependent Claim
13 words
The therapeutic agent of claim 2, wherein the gram negative bacteria are Serratia.
Claim 7
Dependent Claim
14 words
The therapeutic agent of claim 5, wherein the gram negative bacteria are Serratia marcescens.
Claim 8
Dependent Claim
13 words
The therapeutic agent of claim 2, wherein the gram negative bacteria are Escherichia.
Claim 9
Dependent Claim
14 words
The therapeutic agent of claim 7, wherein the gram negative bacteria are Escherichia coli.
Claim 10
Dependent Claim
16 words
The therapeutic agent of claim 1, wherein the lipopolysaccharide is treated by hydroxylamine or alkaline hydroxylamine.
Claim 11
Dependent Claim
18 words
The therapeutic agent of claim 1, wherein the suspension contains the cord factor of the acid fast bacteria.
Claim 12
Dependent Claim
13 words
The therapeutic agent of claim 10, wherein the acid fast bacteria are Mycobacterium.
Claim 13
Dependent Claim
25 words
The therapeutic agent of claim 11, wherein the acid fast bacteria are selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium smegmatis.
Claim 14
Dependent Claim
17 words
The therapeutic agent of claim 1, wherein a mineral oil is used to prepare the oil-in-water suspension.
Claim 15
Dependent Claim
19 words
The therapeutic agent of claim 13 wherein the proportions of (A) to (B) are 6:1 to 1:1 by weight.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |