US4456590A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Heat treatment of lyophilized blood clotting factor VIII concentrate
Assignee: Cedars Sinai Medical Center A Corp Of Ca
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Filing: 1982-05-13
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Granted: 1984-06-26
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Expires: 2002-05-13
Abstract
Abstract A method for treating blood products to eliminate hepatitis virus present therein is disclosed. Blood products treated according to the method are first lyophilized and then subjected to heat for a period of time sufficient to inactivate the hepatitis virus. At the conclusion of the heating step the blood product can be reconstituted using sterile water or a like diluent. No adverse effects on blood product activity following treatment have been observed. The method has special applicability to blood plasma fractions such as Factor VIII, Factor IX and fibrinogen.
Inventors
- 👤 Alan Rubinstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:07
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/644; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K39/00; A61K39/12; A61K39/29; A61L; A61L2/00; A61L2/02; A61L2/04; A61L2/08; A61L2/12; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C12Y; C12Y304/00; C12Y304/21; C12Y304/21022; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
89 words
A method for treating blood clotting Factor VIII concentrate in order to minimize the effect of any hepatitis virus present in the blood clotting Factor VIII concentrate, said method comprising the steps of: lyophilizing the blood clotting Factor VIII concentrate, followed by; heating the lyophilized blood clotting Factor VIII concentrate at a predetermined temperature of at least about 60° C. for a period of time sufficient to render hepatitis virus present in the blood clotting Factor VIII concentrate non-infectious, said heating generally decreasing as said predetermined temperature is increased.
Claim 2
Independent Claim
89 words
A method for treating blood clotting Factor VIII concentrate in order to minimize the effect of any hepatitis virus present in the blood clotting Factor VIII concentrate, said method comprising the steps of: lyophilizing the blood clotting Factor VIII concentrate, followed by; heating the lyophilized blood clotting Factor VIII concentrate at a predetermined temperature of at least about 60° C. for a period of time sufficient to render hepatitis virus present in the blood clotting Factor VIII concentrate non-infectious, said heating generally decreasing as said predetermined temperature is increased.
Claim 3
Dependent Claim
19 words
The method claimed in claim 1 wherein said predetermined temperature is between about 60° C. and about 100° C.
Claim 4
Dependent Claim
19 words
The method claimed in claim 1 wherein said predetermined temperature is between about 60° C. and about 125° C.
Claim 5
Dependent Claim
36 words
The method claimed in claim 1 further comprising: adding sterile water to the lyophilized blood Factor VIII concentrate following completion of said heating step until solubilization of the lyophilized blood clotting Factor VIII concentrate is achieved.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-26 | 1987-12-26 | 1988-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-26 | 1991-12-26 | 1992-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-26 | 1995-12-26 | 1996-06-26 | $7700.00 | Window Closed / Lapsed |