US4457864A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic analogues of α-melanotropin
Assignee: University Patents Inc
•
Filing: 1981-10-23
•
Granted: 1984-07-03
•
Expires: 2001-10-23
Abstract
Abstract Analogues of the tridecapeptide hormone, α-melanotropin (a-melanocyte stimulating hormone, α-MSH) of the formula: Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg 8 -Trp 9 -Gly 10 -Lys 11 -Pro 12 -Val 13 -NH 2 wherein X and Y are amino acid residues and X is in a D-isomeric configuration. Preferred analogues, e.g. [Nle 4 , D-Phe 7 ]-α-MSH, display increased in vitro and in vivo potency, prolongation and serum stability characteristics and may be covalently bonded to other elements or compounds (e.g., radioisotopes of iodine) without significant loss of biological activity.
Inventors
- 👤 Victor J. Hruby
- 👤 Mac E. Hadley
- 👤 Christopher B. Heward
- 👤 Tomi K. Sawyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:21
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/695; C07K14/6955; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
40 words
A tridecapeptide of the formula: Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg.sup.8 -Trp.sup.9 -Gly.sup.10 -Lys.sup.11 -Pro.sup.12 -Val.sup.13 -NH.sub.2 X is D-phenylalinine Y is methionine or norleucine, and all remaining amino acid residues in said tridecapeptide are in L-isomeric configuration.
Claim 2
Dependent Claim
40 words
A tridecapeptide of the formula: Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg.sup.8 -Trp.sup.9 -Gly.sup.10 -Lys.sup.11 -Pro.sup.12 -Val.sup.13 -NH.sub.2 X is D-phenylalinine Y is methionine or norleucine, and all remaining amino acid residues in said tridecapeptide are in L-isomeric configuration.
Claim 3
Dependent Claim
11 words
A tridecapeptide according to claim 1 which is [D-Phe 7 ]-α-MSH.
Claim 4
Dependent Claim
14 words
A tridecapeptide according to claim 1 which is [Nle 4 , D-Phe 7 ]-α-MSH.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-03 | 1988-01-02 | 1988-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-03 | 1992-01-02 | 1992-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-03 | 1996-01-02 | 1996-07-03 | $7700.00 | Window Closed / Lapsed |