US4462943A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carboxyalkyl amino acid derivatives of various substituted prolines
Assignee: ER Squibb and Sons LLC
•
Filing: 1981-09-28
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Granted: 1984-07-31
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Expires: 2001-09-28
Abstract
Abstract Carboxyalkyl dipeptides of the formula ##STR1## wherein R 4 is a 3-, 4-, 5-, or 4,4-substituted proline are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.
Inventors
- 👤 Edward W. Petrillo, Jr.
- 👤 Eric M. Gordon
- 👤 John Krapcho
- 👤 Peter W. Sprague
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:50
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/801
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
18 words
A compound of the formula ##STR239## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 2
Dependent Claim
18 words
A compound of the formula ##STR239## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 3
Dependent Claim
18 words
A compound of the formula ##STR240## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 4
Dependent Claim
18 words
A compound of the formula ##STR240## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 5
Dependent Claim
18 words
A compound of the formula ##STR241## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 6
Dependent Claim
18 words
A compound of the formula ##STR241## and a pharmaceutically acceptable salt thereof wherein R is hydroxy or ethoxy.
Claim 7
Dependent Claim
6 words
The compound of claim 1, (cis)-1-[N-[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-4-phenyl-L-proline.
Claim 8
Dependent Claim
6 words
The compound of claim 2, (trans)-1-[N-[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-4-(methylthio)-L-proline.
Claim 9
Dependent Claim
6 words
The compound of claim 3, [1(S),4R]-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-4-(phenylthio)-L-proline.
References Cited (Backward Citations)
US4105776A
Cited
US4154935A
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GB2027025A
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GB2028327A
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EP0012401A1
Cited
GB2039478A
Cited
US4217359A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |