Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation

Claim 1

A compound having the structural formula ##STR72## and including all stereoisomers thereof; wherein Z is ##STR73## n is 1 or 2; R 1 is H or lower alkyl; B is --CH═CH--, --C.tbd.C-- or (CH 2 ) 2 ; Y is alkyl; aryl-lower alkyl; alkenyl; alkynyl; aryl, pyridyl, pyridyl-lower alkyl; substituted pyridyl wherein the substituent is 1 or 2 halogen or lower alkyl groups; thienyl; thienylalkyl; substituted thienyl wherein the substituent is 1 or 2 halogen or lower alkyl groups; cycloalkyl; substituted cycloalkyl wherein the substituent is 1 or 2 halogens, 1 or 2 lower alkyl groups or lower alkoxy groups; cycloalkylalkyl or substituted cycloalkylalkyl wherein the substituent is 1 or 2 halogens, 1 or 2 lower alkyl groups or lower alkoxy groups; y is 0 or 1, where y is 1, R 3 is H or lower alkyl; R 2 is lower alkyl, lower alkoxy, aryl, alkylamino, arylamino, aryloxy, pyridinyl or cycloalkyl or where y is 0 as indicated by ##STR74## R 2 can be a --(CH 2 ) x linking group (wherein x is 3, 4 or 5) which together with ##STR75## may form an N-containing 5-, 6- or 7-membered heterocycle, with the proviso that when R 3 is H, R 2 is lower alkoxy; R 4 is lower alkyl, cycloalkyl, aryl, aryl-alkyl or alkanoyl; p is 0 to 5; m is 1 to 8; and R 5 is lower alkyl, lower alkoxy, aralkoxy or ##STR76## wherein R 6 is lower alkyl or phenyl; wherein alkyl or lower alkyl by itself or part of another group contains 1 to 12 carbons, aryl by itself or part of another part refers to a monocyclic or bicyclic aromatic group which contains 6 to 10 carbon atoms in the ring and which ring may be unsubstituted or contain 1 or 2 halogen, lower alkyl and/or lower alkoxy groups, alkenyl contains 3 to 6 carbon atoms, alkynyl contains 3 to 6 carbon atoms, and cycloalkyl contains 3 to 6 carbon atoms, and cycloalkyl contains 3 to 12 carbon atoms in the ring.