US4472398A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Condensed pyrimidines
Assignee: Chinoin Private Co Ltd
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Filing: 1979-02-23
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Granted: 1984-09-18
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Expires: 1999-02-23
Abstract
Abstract Antiphlogistic and anticoagulant compounds of the formula: ##STR1## wherein m is 0, 1 or 2, n is 0, 1 or 2, R is C 1 to C 6 alkyl, R 1 is hydrogen, or C 1 to C 6 alkyl, R 2 is hydrogen, C 1 to C 6 alkyl, substituted or unsubstituted amino, substituted or unsubstituted hydroxy, carboxy or a group derived from a carboxylic acid or R 1 and R 2 together form a --(CH═CH) 2 --group and R 5 is 0 or imino or substituted imino.
Inventors
- 👤 Zoltan Meszaros
- 👤 Jozsef Knoll
- 👤 Istvan Hermecz
- 👤 Agnes Horvath
- 👤 Sandor Virag
- 👤 nee Debreczy Lelle Vasvari
- 👤 Agoston David
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:08
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00; A61P43/00; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
16 words
A compound selected from the group consisting of racemic or optically active: 1,6-dimethyl-3-[N-(2-phenylethyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; and 1,6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido-(1,2-a)pyrimidine.
Claim 2
Dependent Claim
16 words
A compound selected from the group consisting of racemic or optically active: 1,6-dimethyl-3-[N-(2-phenylethyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; 1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)pyrimidine; and 1,6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido-(1,2-a)pyrimidine.
Claim 3
Dependent Claim
31 words
An antiphlogistic method of treatment which comprises administering to an afflicted animal a pharmaceutically effective amount of the compound defined in claim 1 in combination with a pharmaceutically acceptable inert carrier.
Claim 4
Dependent Claim
141 words
An antiphlogistic method of treatment which comprises the step of administering to an afflicted animal subject an effective amount of a racemic or optically active compound of the formula (I) ##STR7## wherein m is 0 or 1; R is C 1 to C 6 alkyl; R 1 is hydrogen or methyl at position 6, 7 or 8; R 2 is hydrogen; R 3 is hydrogen, C 1 to C 4 alkyl, C 1 to C 4 alkyl substituted by C 1 to C 4 alkoxycarbonyl or by one or two phenyl groups, phenyl, halophenyl, C 1 to C 4 alkyl-phenyl, C 1 to C 4 alkoxy-phenyl, nitro-phenyl, or C 1 to C 4 alkanoyl; R 4 is hydrogen or C 1 to C 4 alkyl; or R 3 and R 4 together with the adjacent nitrogen atom form a piperidino group.
Claim 5
Dependent Claim
141 words
An antiphlogistic method of treatment which comprises the step of administering to an afflicted animal subject an effective amount of a racemic or optically active compound of the formula (I) ##STR7## wherein m is 0 or 1; R is C 1 to C 6 alkyl; R 1 is hydrogen or methyl at position 6, 7 or 8; R 2 is hydrogen; R 3 is hydrogen, C 1 to C 4 alkyl, C 1 to C 4 alkyl substituted by C 1 to C 4 alkoxycarbonyl or by one or two phenyl groups, phenyl, halophenyl, C 1 to C 4 alkyl-phenyl, C 1 to C 4 alkoxy-phenyl, nitro-phenyl, or C 1 to C 4 alkanoyl; R 4 is hydrogen or C 1 to C 4 alkyl; or R 3 and R 4 together with the adjacent nitrogen atom form a piperidino group.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |