US4473496A
Expired / Lapsed
US
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Intramolecularly crosslinked hemoglobin
Assignee: United States Department of the Army
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Filing: 1983-10-28
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Granted: 1984-09-25
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Expires: 2003-10-28
Abstract
Abstract This invention relates to molecular modification of hemoglobin by utilizan of a class of α, ω-dialdelhydes having a chain length of 5 to 7 members and substituted with at least one negatively charged group such as a phosphate moiety. A subject α, ω-dialdehyde can be synthesized by sodium periodate oxidation of a phosphorylated ribose such as adenosine-5'-triphosphate or 5-phosphoribosyl-1-pyrophosphate. The compounds of this invention can be advantageously used for intramolecularly crosslinking hemoglobin for resuscitative purposes.
Inventors
- 👤 Patrick J. Scannon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:13
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
47 words
Hemoglobin intramolecularly crosslinked in the 2,3 diphosphoglycerate pocket with a compound of the group of α,ω-dialdehydes derived from oxidation of a 5,6 or 7-membered nonaryl carbocylic or heterocyclic compound substituted with at least one negatively charged group having a 1,2-diol moiety isolated from said negatively charged group.
Claim 2
Dependent Claim
47 words
Hemoglobin intramolecularly crosslinked in the 2,3 diphosphoglycerate pocket with a compound of the group of α,ω-dialdehydes derived from oxidation of a 5,6 or 7-membered nonaryl carbocylic or heterocyclic compound substituted with at least one negatively charged group having a 1,2-diol moiety isolated from said negatively charged group.
Claim 3
Dependent Claim
13 words
Hemoglobin according to claim 1 wherein the heterocyclic compound comprises a furanose ring.
Claim 4
Dependent Claim
12 words
Hemoglobin according to claim 2 wherein the heterocyclic compound is a ribose.
Claim 5
Dependent Claim
11 words
Hemoglobin according to claim 3 wherein the heterocyclic compound is adenosine-5'-monophosphate.
Claim 6
Dependent Claim
11 words
Hemoglobin according to claim 3 wherein the heterocyclic compound is adenosine-5'-diphosphate.
Claim 7
Dependent Claim
11 words
Hemoglobin according to claim 3 wherein the heterocyclic compound is adenosine-5'-triphosphate.
Claim 8
Dependent Claim
11 words
Hemoglobin according to claim 3 wherein the heterocyclic compound is 5-phosphoribosyl-1-pyrophosphate.
References Cited (Backward Citations)
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Cited
US3925344A
Cited
US4336248A
Cited
US4001401A
Cited
US4061736A
Cited
US4136093A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-25 | 1988-03-26 | 1988-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-25 | 1992-03-26 | 1992-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-25 | 1996-03-26 | 1996-09-25 | $7700.00 | Window Closed / Lapsed |