US4489053A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable radioactive diagnostic agent and a non-radioactive carrier therefor
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1982-12-02
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Granted: 1984-12-18
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Expires: 2002-12-02
Abstract
Abstract A stable non-radioactive carrier for use in production of 99m Tc-labeled radioactive diagnostic agent comprising a chelating agent, a water-soluble reducing agent for pertechnetate and a stabilizer chosen from ascorbic acid and erythorbic acid, and their pharmaceutically acceptable salts and esters in an amount of more than about 100 moles per 1 mol of said water-soluble reducing agent.
Inventors
- 👤 Makoto Azuma
- 👤 Masaaki Hazue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:45
CPC Classifications
A; A61; A61B; A61B6/00; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
149 words
A stable non-radioactive carrier for use in production of 99m Tc-labeled radioactive diagnostic agent comprising a chelating agent, a water-soluble reducing agent for pertechnetate and a stabilizer chosen from ascorbic acid and erythorbic acid, and their pharmaceutically acceptable salts and esters in an amount of more than about 100 moles per 1 mol of said water-soluble reducing agent and in an amount less than that showing any material toxicity, said chelating agent comprising N-pyridoxyl-α-amino acid of the formula ##STR2## wherein R 1 and R 2 are each an atom or an atomic group which can be present in α-amino acid of the formula ##STR3## and R 3 , R 4 , R 5 and R 6 are each a hydrogen atom, a halogen atom, a C 1 -C 10 alkyl group or a C 1 -C 10 alkyl group substituted with at least one hydrophilic group, or its salt.
Claim 2
Dependent Claim
149 words
A stable non-radioactive carrier for use in production of 99m Tc-labeled radioactive diagnostic agent comprising a chelating agent, a water-soluble reducing agent for pertechnetate and a stabilizer chosen from ascorbic acid and erythorbic acid, and their pharmaceutically acceptable salts and esters in an amount of more than about 100 moles per 1 mol of said water-soluble reducing agent and in an amount less than that showing any material toxicity, said chelating agent comprising N-pyridoxyl-α-amino acid of the formula ##STR2## wherein R 1 and R 2 are each an atom or an atomic group which can be present in α-amino acid of the formula ##STR3## and R 3 , R 4 , R 5 and R 6 are each a hydrogen atom, a halogen atom, a C 1 -C 10 alkyl group or a C 1 -C 10 alkyl group substituted with at least one hydrophilic group, or its salt.
Claim 3
Dependent Claim
17 words
The stable non-radioactive carrier according to claim 1, wherein the water-soluble reducing agent is a stannous salt.
Claim 4
Dependent Claim
153 words
A stable 99m Tc-labeled radioactive diagnostic agent which is produced by contacting 99m Tc-containing pertechnetate with a non-radioactive carrier comprising a chelating agent, a water-soluble reducing agent for pertechnetate and a stabilizer chosen from ascorbic acid and erythorbic acid, and pharmaceutically acceptable salts and esters in an amount of more than about 100 moles per 1 mol of said water-soluble reducing agent and in an amount less than that showing any material toxicity, said chelating agent comprising N-pyridoxyl-α-amino acid of the formula ##STR4## wherein R 1 and R 2 are each an atom or an atomic group which can be present in α-amino acid of the formula ##STR5## and R 3 , R 4 , R 5 and R 6 are each a hydrogen atom, a halogen atom, a C 1 -C 10 alkyl group or a C 1 -C 10 alkyl group substituted with at least one hydrophilic group, or its salt.
Claim 5
Dependent Claim
153 words
A stable 99m Tc-labeled radioactive diagnostic agent which is produced by contacting 99m Tc-containing pertechnetate with a non-radioactive carrier comprising a chelating agent, a water-soluble reducing agent for pertechnetate and a stabilizer chosen from ascorbic acid and erythorbic acid, and pharmaceutically acceptable salts and esters in an amount of more than about 100 moles per 1 mol of said water-soluble reducing agent and in an amount less than that showing any material toxicity, said chelating agent comprising N-pyridoxyl-α-amino acid of the formula ##STR4## wherein R 1 and R 2 are each an atom or an atomic group which can be present in α-amino acid of the formula ##STR5## and R 3 , R 4 , R 5 and R 6 are each a hydrogen atom, a halogen atom, a C 1 -C 10 alkyl group or a C 1 -C 10 alkyl group substituted with at least one hydrophilic group, or its salt.
Claim 6
Dependent Claim
20 words
The stable 99m Tc-labeled radioactive diagnostic agent according to claim 3, wherein the water-soluble reducing agent is a stannous salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |