US4491574A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reduction of high dose aspirin toxicity by dietary vitamin A
Assignee: Albert Einstein College of Medicine
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Filing: 1983-03-02
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Granted: 1985-01-01
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Expires: 2003-03-02
Abstract
Abstract The present invention is directed to a development for alleviating the adverse side-effects of taking non-steroid analgesics and anti-inflammatory agents such as aspirin, by also ingesting vitamin A (or B-carotene) formulations. It has been found that vitamin A ingestion has a salutary and therapeutic effect, in that the vitamin A decreases toxicity, including ulcerogenesis, due to ingestion of such agents, e.g. aspirin. Aspirin per se is a very effective medication with pronounced analgesic properties, including the temporary relief of minor aches and pains, and is widely used (in small amounts) with no ill effects. However, since aspirin is a mild anti-coagulant, it sometimes causes bleeding of stomach ulcers, or aggravates pre-existing conditions of that nature. Thus the concomitant administration of vitamin A per se to humans taking aspirin is very effective in decreasing toxicity and inhibiting ulcerogenesis and bleeding in the stomach. Also effective, but less so, is B-carotene, a vitamin A precursor, which when assimilated into the body yields vitamin A or a derivative thereof.
Inventors
- 👤 Eli Seifter
- 👤 Giuseppe Rettura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 07:10
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K31/618; A61K31/621
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
86 words
A method for reducing toxicity and inhibiting ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, comprising the concomitant ingestion of an amount of vitamin A or a precursor of vitamin A effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, the amount being such as to provide a daily dosage greater than 10,000 I.U. but less than a toxic amount of vitamin A or vitamin A precursor.
Claim 2
Independent Claim
86 words
A method for reducing toxicity and inhibiting ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, comprising the concomitant ingestion of an amount of vitamin A or a precursor of vitamin A effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, the amount being such as to provide a daily dosage greater than 10,000 I.U. but less than a toxic amount of vitamin A or vitamin A precursor.
Claim 3
Dependent Claim
35 words
The method of claim 1 in which the effective amount of vitamin A or a precursor of vitamin A is such as to provide a daily dosage in the range of 10,000 to 30,000 I.U.
Claim 4
Dependent Claim
85 words
An ingestible composition which does not exhibit the adverse side effects caused by the ingestion of aspirin in mammals, comprising aspirin and an amount of vitamin A or vitamin A precursor effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, in which the amount of vitamin A or vitamin A precursor is greater than 1 I.U. per milligram of aspirin but less than a toxic amount of vitamin A or vitamin A precursor.
Claim 5
Dependent Claim
85 words
An ingestible composition which does not exhibit the adverse side effects caused by the ingestion of aspirin in mammals, comprising aspirin and an amount of vitamin A or vitamin A precursor effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, in which the amount of vitamin A or vitamin A precursor is greater than 1 I.U. per milligram of aspirin but less than a toxic amount of vitamin A or vitamin A precursor.
Claim 6
Dependent Claim
18 words
The method of claim 1 or the composition of claim 3 in which said mammal is a human.
Claim 7
Dependent Claim
26 words
The composition of claim 3 in which the amount of vitamin A or vitamin A precursor per milligram of aspirin is from 1 to 10 I.U.
Claim 8
Dependent Claim
19 words
The method of claim 1 or the composition of claim 3 in which said vitamin A precursoe is B-carotene.
Claim 9
Dependent Claim
26 words
The method of claim 1 or the composition of claim 3 in which said vitamin A comprises transretinyl palmitate, transretinyl acetate, or other effective retinyl esters.
Claim 10
Dependent Claim
68 words
An ingestible composition which does not exhibit the adverse side effects caused by the ingestion of aspirin in mammals, comprising aspirin in the range of 1.25 to 20 grains of U.S.P. analgesic aspirin and an amount of vitamin A or a precursor of vitamin A effective to reduce the toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of said aspirin.
Claim 11
Dependent Claim
68 words
An ingestible composition which does not exhibit the adverse side effects caused by the ingestion of aspirin in mammals, comprising aspirin in the range of 1.25 to 20 grains of U.S.P. analgesic aspirin and an amount of vitamin A or a precursor of vitamin A effective to reduce the toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of said aspirin.
Claim 12
Independent Claim
72 words
A method for reducing toxicity and inhibiting ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, comprising the concomitant ingestion of aspirin in the range of 1.25 to 20 U.S.P. analgesic aspirin and an amount of vitamin A or a precursor of vitamin A effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of said aspirin.
Claim 13
Independent Claim
72 words
A method for reducing toxicity and inhibiting ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of aspirin, comprising the concomitant ingestion of aspirin in the range of 1.25 to 20 U.S.P. analgesic aspirin and an amount of vitamin A or a precursor of vitamin A effective to reduce toxicity and inhibit ulcerogenesis and bleeding in the stomach of a mammal due to the ingestion of said aspirin.
Claim 14
Dependent Claim
18 words
The composition of claim 8 or the method of claim 9 in which said mammal is a human.
Claim 15
Dependent Claim
30 words
The composition of claim 8 or the method of claim 9 in which the vitamin A is in the form of transretinyl palmitate, transretinyl acetate or other effective retinyl esters.
Claim 16
Dependent Claim
19 words
The composition of claim 8 or the method of claim 9 in which said vitamin A precursor is B-carotene.
Claim 17
Dependent Claim
37 words
The method of claim 9 in which said concomitant ingestion of an effective amount of vitamin A or a precursor of vitamin A takes place between one hour before and one hour after said ingestion of aspirin.
Claim 18
Dependent Claim
32 words
The method of claim 9 in which the effective amount of vitamin A or a precursor of vitamin A is ingested by being blended into food which is ingested by said mammal.
Claim 19
Dependent Claim
35 words
The method of claim 9 in which said effective amount of vitamin A or a precursor of vitamin A is such as to provide a daily dosage in the range of 10,000 to 30,000 I.U.
References Cited (Backward Citations)
US3966967A
Cited
US4182770A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-01 | 1988-07-02 | 1989-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-01 | 1992-07-02 | 1993-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-01 | 1996-07-02 | 1997-01-01 | $7700.00 | Window Closed / Lapsed |