US4504413A
Expired / Lapsed
US
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Acetaminophen analogs, antigens, and antibodies
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1983-11-17
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Granted: 1985-03-12
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Expires: 2003-11-17
Abstract
Abstract Carbonyl derivatives of acetaminophen are provided for use in homogeneous enzyme immunoassays for acetaminophen. The derivatives are conjugated to antigenic substances for the preparation of antisera specific to acetaminophen, and to enzymes for the preparation of enzyme conjugates which compete with acetaminophen for antibody binding sites in a typical assay.
Inventors
- 👤 Pyare Khanna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:29
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/535; G01N33/94; G01N33/9486; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
99 words
A compound of the formula ##STR3## wherein: X is methyl or --R--(CO) m Y is --R 1 --CO--NH--R 2 (CO) m when X is methyl, and hydrogen when X is --R--(CO) m R, R 1 , and R 2 are independently aliphatic linking groups of from 1 to 12 carbon atoms each; Z is a poly(amino acid) residue which is an enzyme; m is zero or one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 2
Dependent Claim
99 words
A compound of the formula ##STR3## wherein: X is methyl or --R--(CO) m Y is --R 1 --CO--NH--R 2 (CO) m when X is methyl, and hydrogen when X is --R--(CO) m R, R 1 , and R 2 are independently aliphatic linking groups of from 1 to 12 carbon atoms each; Z is a poly(amino acid) residue which is an enzyme; m is zero or one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 3
Dependent Claim
67 words
A compound of the formula: ##STR4## wherein: R is a aliphatic linking froup of from 1 to 12 carbon atoms; Z is a poly(amino acid) residue which is an enzyme; m is zero or one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 4
Dependent Claim
67 words
A compound of the formula: ##STR4## wherein: R is a aliphatic linking froup of from 1 to 12 carbon atoms; Z is a poly(amino acid) residue which is an enzyme; m is zero or one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 5
Dependent Claim
17 words
A compound according to claim 2 in which R is fully separated and has a straight-chain configuration.
Claim 6
Dependent Claim
24 words
A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 2 to 8 carbon atoms.
Claim 7
Dependent Claim
24 words
A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 3 to 6 carbon atoms.
Claim 8
Dependent Claim
127 words
A compound of the formula: ##STR5## wherein: R 1 is an aliphatic linking group of from 1 to 12 carbon atoms; R 2 is an aliphatic linking group of from 1 to 12 carbon atoms; Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, or a group capable of forming an activated ester capable of amide formation with an amino acid in an aqueous medium, or a poly(amino acid) residue which is antigenic or an enzyme; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 9
Dependent Claim
127 words
A compound of the formula: ##STR5## wherein: R 1 is an aliphatic linking group of from 1 to 12 carbon atoms; R 2 is an aliphatic linking group of from 1 to 12 carbon atoms; Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, or a group capable of forming an activated ester capable of amide formation with an amino acid in an aqueous medium, or a poly(amino acid) residue which is antigenic or an enzyme; m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
Claim 10
Dependent Claim
22 words
A compound according to claim 6 in which R 1 and R 2 are each fully saturated each has a straight-chain configuration.
Claim 11
Dependent Claim
31 words
A compound according to claim 6 in which R 1 and R 2 are each fully saturated, each has a straight-chain configuration, and each contains from 1 to 6 carbon atoms.
Claim 12
Dependent Claim
43 words
A compound according to claim 6 in which R 1 and R 2 are each fully saturated and each has a straight-chain configuration, and R 1 contains from 1 to 4 carbon atoms, and R 2 contains from 1 to 3 carbon atoms.
Claim 13
Dependent Claim
36 words
A compound according to claims 1, 2, or 6 in which Z in an enzyme having a molecular weight of from about 10,000 to about 1,000,000 daltons, and n ranges from about 2 to about 20.
Claim 14
Dependent Claim
15 words
A compound according to claims 1, 2, or 6 in which Z is glucose-6-phosphate dehydrogenase.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-03-11 | 1988-09-10 | 1989-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-03-11 | 1992-09-10 | 1993-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-03-11 | 1996-09-10 | 1997-03-12 | $7700.00 | Window Closed / Lapsed |