US4515767A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
Assignee: Dow Chemical Co
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Filing: 1983-06-20
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Granted: 1985-05-07
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Expires: 2003-06-20
Abstract
Abstract Complexes of radionuclides with a compound of the formula <IMAGE> wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof. Tc-99m complexes have been found useful for imaging the skeletal structure of animals.
Inventors
- 👤 Jaime Simon
- 👤 David A. Wilson
- 👤 Wynn A. Volkert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:49
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0487; A61K51/0404; A61K51/0406; C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3817; A61K2123/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
81 words
A bone seeking complex of a radioactive nuclide and a compound having the structural formula ##STR3## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof.
Claim 2
Dependent Claim
81 words
A bone seeking complex of a radioactive nuclide and a compound having the structural formula ##STR3## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof.
Claim 3
Dependent Claim
19 words
The complex of claim 1 wherein A, B, X and Y are each methylenephosphonic acid radicals or salts thereof.
Claim 4
Dependent Claim
12 words
The complex of claim 1 wherein the radioactive nuclide is Technetium-99 m.
Claim 5
Dependent Claim
12 words
The complex of claim 2 wherein the radioactive nuclide is Technetium-99 m.
Claim 6
Dependent Claim
16 words
A composition comprising the complex of claim 3 and a reducing agent in a saline solution.
Claim 7
Dependent Claim
16 words
A composition comprising the complex of claim 4 and a reducing agent in a saline solution.
Claim 8
Dependent Claim
13 words
The composition of claim 5 wherein the reducing agent is Sn 2+ .
Claim 9
Dependent Claim
13 words
The composition of claim 6 wherein the reducing agent is Sn 2+ .
Claim 10
Dependent Claim
15 words
The composition of claim 1 wherein the radioactive nuclide is a beta or alpha emitter.
Claim 11
Dependent Claim
15 words
The composition of claim 2 wherein the radioactive nuclide is a beta or alpha emitter.
Claim 12
Dependent Claim
10 words
The composition of claim 9 wherein the radionuclide is Re-186.
Claim 13
Dependent Claim
10 words
The composition of claim 10 wherein the radionuclide is Re-186.
Claim 14
Dependent Claim
16 words
A composition comprising the complex of claim 11 and a reducing agent in a saline solution.
Claim 15
Dependent Claim
16 words
A composition comprising the complex of claim 12 and a reducing agent in a saline solution.
Claim 16
Dependent Claim
12 words
The composition of claim 13 wherein Sn 2+ is the reducing agent.
Claim 17
Dependent Claim
12 words
The composition of claim 14 wherein Sn 2+ is the reducing agent.
Claim 18
Dependent Claim
18 words
The composition of claim 9 wherein the radionuclide is one of the lanthanide series of the periodic table.
Claim 19
Dependent Claim
18 words
The composition of claim 10 wherein the radionuclide is one of the lanthanide series of the periodic table.
Claim 20
Dependent Claim
96 words
In a process in which the skeletal system is imaged with a complex of a radionuclide the improvement which comprises employing as the complexing agent a compound having the formula ##STR4## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof.
Claim 21
Dependent Claim
96 words
In a process in which the skeletal system is imaged with a complex of a radionuclide the improvement which comprises employing as the complexing agent a compound having the formula ##STR4## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts, thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof.
Claim 22
Dependent Claim
20 words
The process of claim 19 wherein A, B, X and Y are each a methylenephosphonic acid or a salt thereof.
References Cited (Backward Citations)
US3989730A
Cited
US3851044A
Cited
US3852414A
Cited
US4016249A
Cited
US4082840A
Cited
US3983227A
Cited
US3931396A
Cited
US4023625A
Cited
US4075314A
Cited
US4387087A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-06 | 1988-11-05 | 1989-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-06 | 1992-11-05 | 1993-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-06 | 1996-11-05 | 1997-05-07 | $7700.00 | Window Closed / Lapsed |