US4522804A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Constant release rate solid oral dosage formulations of propranolol
Assignee: Verex Laboratories Inc
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Filing: 1984-02-16
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Granted: 1985-06-11
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Expires: 2004-02-16
Abstract
Abstract A constant order release rate solid oral dosage formulation of propranolol or a pharmaceutically acceptable salt thereof, said formulation comprising: a therapeutically effective amount of propranolol or a pharmaceutically acceptable salt; from about 0.5 to 6.0 weight percent of an acid-retardant or hydrophobic cellulose derivative; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil: from about 1 to 20 weight percent of an acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 3.0 percent of a lubricant.
Inventors
- 👤 James M. Dunn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 13:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/275; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61K9/2013; A61K9/2022; A61K9/2027; A61K9/205; A61K9/2054
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
99 words
A constant order release rate solid oral dosage formulation of propranolol or a pharmaceutically acceptable salt thereof, said formulation comprising: a therapeutically effective amount of propranolol or pharmaceutically acceptable salt thereof, from about 0.5 to 6.0 weight percent of microcrystalline cellulose alone or with one or more acid-retardant hydrophobic cellulose derivatives; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil; from about 1 to 20 weight percent of pharmaceutically acceptable acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 3.0 weight percent of a tableting lubricant.
Claim 2
Dependent Claim
99 words
A constant order release rate solid oral dosage formulation of propranolol or a pharmaceutically acceptable salt thereof, said formulation comprising: a therapeutically effective amount of propranolol or pharmaceutically acceptable salt thereof, from about 0.5 to 6.0 weight percent of microcrystalline cellulose alone or with one or more acid-retardant hydrophobic cellulose derivatives; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil; from about 1 to 20 weight percent of pharmaceutically acceptable acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 3.0 weight percent of a tableting lubricant.
Claim 3
Dependent Claim
15 words
The formulation of claim 1 wherein said acid retardant cellulose derivative is cellulose acetate phthalate.
Claim 4
Dependent Claim
14 words
The formulation of claim 1 wherein said hydrogenated vegetable oil is hydrogenated cottonseed oil.
Claim 5
Dependent Claim
13 words
The formulation of claim 1 wherein said acrylic acid polymer is carboxypolymethylene carbomer.
Claim 6
Dependent Claim
24 words
The formulation of claim 1 wherein said acid retardant cellulose derivative is cellulose acetate phthalate, and said hydrogenated vegetable oil is hydrogenated cottonseed oil.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-10 | 1988-12-10 | 1989-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-10 | 1992-12-10 | 1993-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-10 | 1996-12-10 | 1997-06-11 | $7700.00 | Window Closed / Lapsed |