US4526787A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-heterocyclic retinoic acid analogues
Assignee: SRI International Inc
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Filing: 1983-03-28
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Granted: 1985-07-02
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Expires: 2003-03-28
Abstract
Abstract A compound of the formula: <IMAGE> where X is <IMAGE> +TR <IMAGE> and R is hydroxy, or an alkoxy with 0 or 1 hydroxy substituent, or aroxy with 0 or 1 hydroxy substituent, or alkoxy monosubstituted phenoxy, or NR1R2 where R1 is hydrogen, or an alkyl or aryl with 0 or 1 hydroxy substituent, and R2 is an alkyl or aryl with 0 or 1 hydroxy substituent. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in ephithelial cells and for treating nonmalignant skin disorders.
Inventors
- 👤 Marcia I. Dawson
- 👤 Rebecca L. S. Chan
- 👤 Peter D. Hobbs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:40
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07D213/44; C07D213/46; C07D213/48; C07D213/60; C07D213/78; C07D213/79; C07D213/80
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
94 words
A compound of the formula: ##STR7## where X is ##STR8## and R is hydroxy, alkoxy of 1 to 10 carbon atoms with 0 or 1 hydroxy substituent, phenoxy, monohydroxyphenoxy, monoalkoxyphenoxy where the alkoxy group contains 1 to 4 carbon atoms with 0 or 1 hydroxy substituent, or --NR 1 R 2 where R 1 is hydrogen, alkyl of 1 to 8 carbon atoms with 0 or 1 hydroxy substituent, phenyl, 4-hydroxyphenyl, or 4-methoxyphenyl, and R 2 is alkyl of 1 to 8 carbon atoms with 0 or 1 hydroxy substituent, phenyl, 4-hydroxyphenyl, or 4-methoxyphenyl.
Claim 2
Dependent Claim
94 words
A compound of the formula: ##STR7## where X is ##STR8## and R is hydroxy, alkoxy of 1 to 10 carbon atoms with 0 or 1 hydroxy substituent, phenoxy, monohydroxyphenoxy, monoalkoxyphenoxy where the alkoxy group contains 1 to 4 carbon atoms with 0 or 1 hydroxy substituent, or --NR 1 R 2 where R 1 is hydrogen, alkyl of 1 to 8 carbon atoms with 0 or 1 hydroxy substituent, phenyl, 4-hydroxyphenyl, or 4-methoxyphenyl, and R 2 is alkyl of 1 to 8 carbon atoms with 0 or 1 hydroxy substituent, phenyl, 4-hydroxyphenyl, or 4-methoxyphenyl.
Claim 3
Dependent Claim
36 words
The compound of claim 1 wherein the alkoxy group represented by R contains 1 to 4 carbon atoms and the alkyl groups represented by R 1 and R 2 each contain 1 to 4 carbon atoms.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein R is ethoxy or hydroxy.
Claim 5
Dependent Claim
6 words
A compound of the formula: ##STR9##
Claim 6
Dependent Claim
6 words
A compound of the formula: ##STR9##
Claim 7
Dependent Claim
32 words
A therapeutic composition for treating a non-malignant skin disorder susceptible to treatment by retinoic acid comprising a therapeutically effective amount of the compound of claim 1, combined with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
32 words
A therapeutic composition for treating a non-malignant skin disorder susceptible to treatment by retinoic acid comprising a therapeutically effective amount of the compound of claim 2, combined with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
32 words
A therapeutic composition for treating a non-malignant skin disorder susceptible to treatment by retinoic acid comprising a therapeutically effective amount of the compound of claim 3, combined with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
32 words
A therapeutic composition for treating a non-malignant skin disorder susceptible to treatment by retinoic acid comprising a therapeutically effective amount of the compound of claim 4, combined with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
33 words
A method of treating a living animal for a non-malignant skin disorder susceptible to treatment by retinoic acid comprising administering a therapeutically effective amount of the compound of claim 1 to the animal.
Claim 12
Dependent Claim
11 words
The method of claim 9 wherein the animal is a human.
Claim 13
Dependent Claim
33 words
A method of treating a living animal for a non-malignant skin disorder susceptible to treatment by retinoic acid comprising administering a therapeutically effective amount of the compound of claim 2 to the animal.
Claim 14
Dependent Claim
11 words
The method of claim 11 where the animal is a human.
Claim 15
Dependent Claim
33 words
A method of treating a living animal for a non-malignant skin disorder susceptible to treatment by retinoic acid comprising administering a therapeutically effective amount of the compound of claim 3 to the animal.
Claim 16
Dependent Claim
11 words
The method of claim 13 wherein the animal is a human.
Claim 17
Dependent Claim
33 words
A method of treating a living animal for a non-malignant skin disorder susceptible to treatment by retinoic acid comprising administering a therapeutically effective amount of the compound of claim 4 to the animal.
Claim 18
Dependent Claim
11 words
The method of claim 15 where the animal is a human.
Claim 19
Dependent Claim
22 words
The therapeutic composition of claim 5 wherein the disorder is icthyoses, a follicular disorder, acne, psoriasis, eczema, atopic dermatitis, or nonspecific dermatitis.
Claim 20
Dependent Claim
21 words
The method of claim 9 wherein the disorder is icthyoses, a follicular disorder, acne, psoriasis, eczema, atopic dermatitis, or nonspecific dermatitis.
References Cited (Backward Citations)
DE2440525A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-01 | 1988-12-31 | 1989-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-01 | 1992-12-31 | 1993-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-01 | 1996-12-31 | 1997-07-02 | $7700.00 | Window Closed / Lapsed |