Abstract The compounds represented by the formula (I) ##STR1## wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R 1 ' is hydrogen, ##STR2## and R 2 ' is amino, --NHCH 2 CO 2 R 3 ', ##STR3## --NHCH 2 CONH 2 or --OR 3 ' wherein R 3 ' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R 1 ' is hydrogen are chemical intermediates in the synthesis of leukotriene antagonists of the formula (II) ##STR4## wherein m and p, are described above and R 1 is hydrogen, amino or ##STR5## R 2 is hydroxyl, amino, --NHCH 2 CO 2 H, ##STR6## --NHCH 2 CONH 2 ; and X is ##STR7## --CO 2 H or --CH 2 OH which are useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.
A compound represented by the structural formula (I) ##STR19## wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R 1 ' is hydrogen, ##STR20## and R 2 ' is amino, --NHCH 2 CO 2 R 3 ', ##STR21## --NHCH 2 CONH 2 or --OR 3 ' wherein R 3 ' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R 1 ' is hydrogen.
Claim 2
Dependent Claim
79 words
A compound represented by the structural formula (I) ##STR19## wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R 1 ' is hydrogen, ##STR20## and R 2 ' is amino, --NHCH 2 CO 2 R 3 ', ##STR21## --NHCH 2 CONH 2 or --OR 3 ' wherein R 3 ' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R 1 ' is hydrogen.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein p is 11.
Claim 4
Dependent Claim
23 words
A compound according to claim 2 wherein m is 1, R 1 ' is hydrogen and R 2 ' is methoxy, designated 2-[(2-carbomethoxyethyl)thio]-3(Z)-hexadecen-1-al.