US4543255A
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Carbocyclic analogs of purine 2'-deoxyribofuranosides
Assignee: SOUTHERN RESEARCH INSTITUTE 2000 NINTH AVENUE SOUTH BIRMINGHAM AL 35255 A CORP OF
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Filing: 1984-05-10
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Granted: 1985-09-24
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Expires: 2004-05-10
Abstract
Abstract There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine 2'-deoxyribofuranosides and 2-amino-6-substituted-8-azapurine 2'-deoxyribofuranosides. The compounds are useful in the treatment of viral infections.
Inventors
- 👤 Y. Fulmer Shealy
- 👤 C. Allen O'Dell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:25
CPC Classifications
C; C07; C07D; C07D473/00; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
32 words
A compound having one of the following formulas ##STR6## wherein X is halogen, an amino group, an alkylamino group, an alkoxy group, or an akylthio group, and Y is oxygen or sulfur.
Claim 2
Dependent Claim
32 words
A compound having one of the following formulas ##STR6## wherein X is halogen, an amino group, an alkylamino group, an alkoxy group, or an akylthio group, and Y is oxygen or sulfur.
Claim 3
Dependent Claim
12 words
A compound as defined in claim 1 which is (1α, 2β, 4α)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-hydroxycyclopentanemethanol
Claim 4
Dependent Claim
12 words
A compound as defined in claim 1 which is (1α, 2β, 4α)-4-(2,6-diamino-9H-purin-9-yl)-2-hydroxycyclopentanemethanol.
Claim 5
Dependent Claim
12 words
A compound as defined in claim 1 which is 2-amino-1,9-dihydro-9-[(1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purin-6-one.
Claim 6
Dependent Claim
12 words
A compound as defined in claim 1 which is 2-amino-1,9-dihydro-9-[1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purine-6-thione.
Claim 7
Dependent Claim
12 words
A compound as defined in claim 1 which is (1α, 2β, 4α)-4-(5-amino-7-chloro-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-2-hydroxycyclopentanemethanol.
Claim 8
Dependent Claim
12 words
A compound as defined in claim 1 which is (1α, 2β, 4α)-4-(5,7-diamino-3-H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-2-hydroxycyclopentanemethanol.
Claim 9
Dependent Claim
12 words
A compound as defined in claim 1 which is 5-amino-3,6-dihydro-3-[(1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one.
Claim 10
Dependent Claim
12 words
A compound as defined in claim 1 which is 5-amino-3,6-dihydro-3-[(1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-thione.
Claim 11
Dependent Claim
59 words
A process for the treatment of a host animal having a herpes virus infection which comprises administering to said host animal a therapeutically effective amount of a compound represented by one of the following formulas: ##STR7## wherein X is halogen, an amino group, an alkylamino group, an alkoxy group, or an akylthio group, and Y is oxygen or sulfur.
Claim 12
Dependent Claim
59 words
A process for the treatment of a host animal having a herpes virus infection which comprises administering to said host animal a therapeutically effective amount of a compound represented by one of the following formulas: ##STR7## wherein X is halogen, an amino group, an alkylamino group, an alkoxy group, or an akylthio group, and Y is oxygen or sulfur.
Claim 13
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is (1α, 2β, 4α)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-hydroxycyclopentanemethanol.
Claim 14
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is (1α, 2β, 4α)-4-(2,6-diamino-9H-purin-9-yl)-2-hydroxycyclopentanemethanol.
Claim 15
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is 2-amino-1,9-dihydro-9-[(1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purin-6-one.
Claim 16
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is 2-amino-1,9-dihydro-9-[1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purine-6-thione.
Claim 17
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is (1α, 2β, 4α)-4-(5-amino-7-chloro-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-2-hydroxycyclopentanemethanol.
Claim 18
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is (1α, 2β, 4α)-4-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-2-hydroxycyclopentanemethanol.
Claim 19
Dependent Claim
14 words
A process as defined in claim 10 wherein said compound is 5-amino-3,6-dihydro-3-[(1α, 3β, 4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-23 | 1989-03-25 | 1989-09-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-23 | 1993-03-25 | 1993-09-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-23 | 1997-03-25 | 1997-09-24 | $7700.00 | Window Closed / Lapsed |