US4564684A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Amino-1-phenyl-2-pyrazolines
Assignee: Individual
•
Filing: 1984-05-23
•
Granted: 1986-01-14
•
Expires: 2004-05-23
Abstract
Abstract Heterocyclic compounds of formula (I) and acid addition salts thereof inhibit arachidonic acid oxygenation and are useful in medicine, for example as anti-inflammatory agents. ##STR1## The compounds of formula (I) may be prepared by any method analogous to those known in the art, for example by the method of G. F. Duffin and J. D. Kendall in J. Chem. Soc. (1954), 408-415. When used in medicine, the compounds of formula (I) may be administered as the compound alone or as a pharmaceutical formulation together with a pharmaceutically acceptable carrier.
Inventors
- 👤 Frederick C. Copp
- 👤 Albert G. Caldwell
- 👤 David Collard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:17
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/76; C07D213/77; A; A61; A61P; A61P29/00; A61P37/00; A61P37/08; A61P43/00; C07D231/00; C07D231/02; C07D231/06; C07D401/00; C07D401/02; C07D401/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
32 words
A compound selected from the group consisting of: 3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(ethylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(n-propylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(iso-propylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(n-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(sec-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(tert-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(methylpropylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(benzylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(N,N-dimethylamino)-1-(4-trifluoromethylphenyl)-2-pyrazoline; 3-(methylamino)-1-(4-chlorophenyl)-2-pyrazoline; 3-(N-methyl-N-ethylamino)-1-(4-chlorophenyl)-2-pyrazoline; 3-(methylamino)-1-(4-fluorophenyl)-5-methyl-2-pyrazoline; 3-(benzylamino)-1-(4-bromophenyl)-4-methyl-2-pyrazoline; 3-(ethylamino)-1-(3-trifluoromethyl-4-fluorophenyl)-2-pyrazoline; 3-(tert-butylamino)-1-(3-trifluoromethyl-4-bromophenyl)-2-pyrazoline; 3-(allylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(cyclohexylmethylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; or an acid addition salt thereof.
Claim 2
Dependent Claim
32 words
A compound selected from the group consisting of: 3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(ethylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(n-propylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(iso-propylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(n-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(sec-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(tert-butylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(methylpropylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(benzylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(N,N-dimethylamino)-1-(4-trifluoromethylphenyl)-2-pyrazoline; 3-(methylamino)-1-(4-chlorophenyl)-2-pyrazoline; 3-(N-methyl-N-ethylamino)-1-(4-chlorophenyl)-2-pyrazoline; 3-(methylamino)-1-(4-fluorophenyl)-5-methyl-2-pyrazoline; 3-(benzylamino)-1-(4-bromophenyl)-4-methyl-2-pyrazoline; 3-(ethylamino)-1-(3-trifluoromethyl-4-fluorophenyl)-2-pyrazoline; 3-(tert-butylamino)-1-(3-trifluoromethyl-4-bromophenyl)-2-pyrazoline; 3-(allylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-(cyclohexylmethylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline; or an acid addition salt thereof.
Claim 3
Dependent Claim
19 words
A compound selected from the group consisting of: 3-methylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-ethylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-propylamino-1-(3-trifluoromethylphenyl)-2-pyrazolinehydrochloride; 3-butylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride; 3-benzylamino-1-(3-trifluoromethylphenyl)-2-pyrazolinehydrochloride; 3-methylamino-1-(4-chlorophenyl)-2-pyrazoline hydrochloride; and 3-(3-methylpropylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride.
Claim 4
Dependent Claim
19 words
A compound selected from the group consisting of: 3-methylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-ethylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline; 3-propylamino-1-(3-trifluoromethylphenyl)-2-pyrazolinehydrochloride; 3-butylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride; 3-benzylamino-1-(3-trifluoromethylphenyl)-2-pyrazolinehydrochloride; 3-methylamino-1-(4-chlorophenyl)-2-pyrazoline hydrochloride; and 3-(3-methylpropylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride.
Claim 5
Dependent Claim
11 words
A compound selected from 3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline or an acid addition salt thereof.
Claim 6
Dependent Claim
11 words
A compound selected from 3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline or an acid addition salt thereof.
Claim 7
Dependent Claim
1 words
3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline.
Claim 8
Dependent Claim
1 words
3-(methylamino)-1-(3-trifluoromethylphenyl)-2-pyrazoline.
Claim 9
Dependent Claim
12 words
A pharmaceutically acceptable acid addition salt of the compound of claim 4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-13 | 1989-07-15 | 1990-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-13 | 1993-07-15 | 1994-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-13 | 1997-07-15 | 1998-01-14 | $7700.00 | Window Closed / Lapsed |