Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies

Abstract

Abstract Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are independently hydrogen, alkyl, carboxy, alkylcarboxy, arylcarboxy, alkyl carbalkoxy, alkanoyl, formyl, nitrile, amino, amino alkyl, alkylamine, carboxamide, halo, trihalomethyl, hydroxy, alkoxy, aryloxy, nitro, sulfonyl, sulfonamide, thio, alkylthio, or R 1 and R 2 can be taken together to form a phenyl ring; B is C or N, in which N can be in any position of the ring; X is O, S, NR 4 , CH 2 Z, CH═N, CH═CH, C.tbd.C, CH 2 ZCH 2 , C═O, C═CR or WC═O; Y is CHCH 2 , C═CH, C--CH 2 , CHCHR 5 , CHC(R 5 ) 2 or CC(R 5 ) 2 ; R 3 is O, OH, OR 4 , SH, SR 4 , NH, HNR 4 or N(R 4 ) 2 ; and M is an integer from 0 to 10; wherein Z is O, S or NR 4 ; R 4 is H, alkyl or aryl; W is O, S or NR 4 ; and R 5 is H, alkyl or fluoro have antiinflammatory and antiallergic activities.

Inventors

• 👤 John H. Musser
• 👤 Utpal R. Chakraborty

Bibliographic Details