US4572199A
Expired / Lapsed
US
⏱️ 0.0 years remaining
System to determine arterial occlusion and other maladies
Assignee: University of New Hampshire
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Filing: 1984-11-30
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Granted: 1986-02-25
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Expires: 2004-11-30
Abstract
Abstract A system for noninvasively sensing ocular pulses of a mammal, which pulses serve as a basis for indicating presence of a disease or malfunctioning body part such as, for example, a condition of arterial occlusion. The system employs piezoelectric transducers to sense the ocular pulses which are analyzed, also, in the case of arterial occlusion with simultaneously obtained ECG signals.
Inventors
- 👤 John R. LaCourse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 08:46
CPC Classifications
A; A61; A61B; A61B3/00; A61B3/10; A61B3/14; A61B5/00; A61B5/24; A61B5/316; A61B5/318; A61B5/346; A61B5/349; A61B5/352; A61B7/00; A61B7/001
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
261 words
Apparatus to achieve noninvasive measurement of ocular pulses in mammals, which pulses serve as a basis for determination of any occlusion of extracranial arteries of the mammal, comprising: a. first piezoelectric transducer means to receive ocular pulses from one eye of the mammal and operable to convert the ocular pulses to a first signal of similar electric pulses, b. second piezoelectric transducer means to receive ocular pulses from the other eye of the mammal and operable to convert the ocular pulses to a second signal of similar electric pulses, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact means positioned to engage simultaneously the corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact means substantially horizontally into engagement with said corneas, c. ECG transducer means to record heartbeats of the mammal in the form of electric signals, and d. display means connected to receive the first signal of similar electric pulses, the second signal of similar electric pulses, and the electric signals, and operable to display the same as a series of waveshapes to permit simultaneous observation and simultaneous comparison of the amplitudes and areas of a waveshape derived from each eye, the amount of distortion of the waveshape derived from each eye, and the delay of the waveshape from each eye with respect to the corresponding ECG signal, to permit an inference of any occlusion of the extracranial arteries of the mammal being checked therefor.
Claim 2
Dependent Claim
261 words
Apparatus to achieve noninvasive measurement of ocular pulses in mammals, which pulses serve as a basis for determination of any occlusion of extracranial arteries of the mammal, comprising: a. first piezoelectric transducer means to receive ocular pulses from one eye of the mammal and operable to convert the ocular pulses to a first signal of similar electric pulses, b. second piezoelectric transducer means to receive ocular pulses from the other eye of the mammal and operable to convert the ocular pulses to a second signal of similar electric pulses, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact means positioned to engage simultaneously the corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact means substantially horizontally into engagement with said corneas, c. ECG transducer means to record heartbeats of the mammal in the form of electric signals, and d. display means connected to receive the first signal of similar electric pulses, the second signal of similar electric pulses, and the electric signals, and operable to display the same as a series of waveshapes to permit simultaneous observation and simultaneous comparison of the amplitudes and areas of a waveshape derived from each eye, the amount of distortion of the waveshape derived from each eye, and the delay of the waveshape from each eye with respect to the corresponding ECG signal, to permit an inference of any occlusion of the extracranial arteries of the mammal being checked therefor.
Claim 3
Dependent Claim
16 words
Apparatus as claimed in claim 1, wherein the support means comprises a pair of three-dimensional micromanipulators.
Claim 4
Dependent Claim
26 words
Apparatus as claimed in claim 1, wherein the piezoelectric transducer means are also operative to produce signals corresponding to the intraocular pulse in both eyes simultaneously.
Claim 5
Dependent Claim
32 words
Apparatus according to claim 1, wherein the eye contact means is a material which is sufficiently insulating so as to protect the mammal wearing the eye contact means from electrical shock hazard.
Claim 6
Dependent Claim
15 words
Apparatus according to claim 4, wherein the material for the eye contact means is rubber.
Claim 7
Dependent Claim
17 words
Apparatus according to claim 4, wherein the eye contact means is replaceably held within a plastic sleeve.
Claim 8
Dependent Claim
15 words
Apparatus according to claim 6, wherein the eye contact means is a contact lens retriever.
Claim 9
Dependent Claim
21 words
Apparatus according to claim 7, wherein the contact lens retriever is presterilized before making contact with the surface of the eye.
Claim 10
Dependent Claim
34 words
Apparatus according to claim 8, wherein the contact lens retriever is disposable after each use so as to minimize the likelihood of infection and transmitted diseases to the wearer of the eye contact means.
Claim 11
Dependent Claim
57 words
Apparatus according to claim 1, the eye contact means having an aperture, the aperture extending from the surface of the eye contact means making contact with the eye to at least one other surface of the eye contact means, to allow easy, rapid, and safe removal of the eye contact means from the surface of the eye.
Claim 12
Dependent Claim
38 words
Apparatus according to claim 1, wherein each eye contact means is attached to its piezoelectric bender by a sleeve to permit the eye contact means to be easily and rapidly installed and replaced and maintain calibration after use.
Claim 13
Dependent Claim
22 words
Apparatus according to claim 11, wherein the material for the sleeve attaching the eye contact means to the piezoelectric bender is plastic.
Claim 14
Dependent Claim
13 words
Apparatus according to claim 11, wherein the material for the sleeve is Teflon.
Claim 15
Dependent Claim
13 words
Apparatus according claim 11, wherein the eye contact means is formed of rubber.
Claim 16
Dependent Claim
244 words
Apparatus according to claim 1, wherein the display means comprises: a. a first isolation amplifier which produces a first variable gain for the first signal of similar electric pulses received from the first piezoelectric transducer means, and which serves to insulate the mammal wearing the eye contact means from electric shock hazards by leakage currents, b. a second isolation amplifier which produces a second variable gain for the second signal of similar electric pulses received from the second piezoelectric transducer means, and which serves to insulate the mammal wearing the eye contact means from electric shock hazards, c. a first variable filter which provides a first waveshaped signal for the first variable gain received from the first isolation amplifier, d. a second variable filter which provides a second waveshaped signal for the second variable gain received from the second isolation amplifier, and e. a readout device which receives the first waveshaped signal from the first variable filter, the second waveshaped signal from the second variable filter, and the electric signal from the ECG transducer, and operable to display the same as a series of waveshapes to permit simultaneous observations and simultaneous comparisons of the amplitudes and the areas of waveshapes derived from each eye, the amount of distortion of the waveshape derived from each eye, and the delay of the waveshape of the ECG signal, to permit an inference of any stenosis or occlusion of the extracranial arteries of the mammal being checked therefor.
Claim 17
Dependent Claim
15 words
Apparatus as claimed in claim 15, wherein the readout device is a strip chart recorder.
Claim 18
Dependent Claim
13 words
Apparatus as claimed in claim 15, wherein the readout devise is an oscilloscope.
Claim 19
Dependent Claim
15 words
Apparatus as claimed in claim 15, wherein the readout device is a magnetic tape recorder.
Claim 20
Dependent Claim
14 words
Apparatus as claimed in claim 15, wherein the readout device is a magnetic disk.
Claim 21
Dependent Claim
203 words
A noninvasive method of measuring the ocular pulses in mammals, which pulses serve as a basis for determination of any stenosis or occlusion in extracranial arteries of the mammal, comprising: a. immobilizing the head of the mammal with the corneas of the eyes of the mammal oriented substantially vertically, b. attaching an ECG lead to at least three limbs of the mammal, to record heartbeats of the mammal in the form of electric signals, c. providing a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement and having eye contact devices positioned to engage said corneas, respectively, for converting ocular pulses to first and second signals of similar electric pulses, respectively, d. moving said eye contact devices substantially horizontally into engagement with the corneas, respectively, e. displaying waveshapes of the electric ECG signal, the first signal of similar electric pulses, and the second signal of similar electric pulses, and f. comparing the series of waveshapes to permit simultaneous observation and simultaneous comparison of simultaneous observation and simultaneous comparison of characteristics of the waveshapes derived from each eye and the ECG to permit an inference of any stenosis or occlusion of the extracranial arteries of the mammal being examined therefor.
Claim 22
Dependent Claim
203 words
A noninvasive method of measuring the ocular pulses in mammals, which pulses serve as a basis for determination of any stenosis or occlusion in extracranial arteries of the mammal, comprising: a. immobilizing the head of the mammal with the corneas of the eyes of the mammal oriented substantially vertically, b. attaching an ECG lead to at least three limbs of the mammal, to record heartbeats of the mammal in the form of electric signals, c. providing a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement and having eye contact devices positioned to engage said corneas, respectively, for converting ocular pulses to first and second signals of similar electric pulses, respectively, d. moving said eye contact devices substantially horizontally into engagement with the corneas, respectively, e. displaying waveshapes of the electric ECG signal, the first signal of similar electric pulses, and the second signal of similar electric pulses, and f. comparing the series of waveshapes to permit simultaneous observation and simultaneous comparison of simultaneous observation and simultaneous comparison of characteristics of the waveshapes derived from each eye and the ECG to permit an inference of any stenosis or occlusion of the extracranial arteries of the mammal being examined therefor.
Claim 23
Dependent Claim
26 words
A method as claimed in claim 3, further comprising employing said piezoelectric benders to produce electric signals corresponding to the intraocular pulse in both eyes simultaneously.
Claim 24
Dependent Claim
19 words
A method as claimed in claim 20, wherein the ECG leads are attached to three limbs of the mammal.
Claim 25
Dependent Claim
29 words
A method as claimed in claim 22, wherein the three limbs to which the ECG leads are attached are the left arm, the left leg, and the right arm.
Claim 26
Dependent Claim
24 words
A method as claimed in claim 20, wherein the total time the eye contact devices engage said corneas is less than about five seconds.
Claim 27
Dependent Claim
22 words
A method as claimed in claim 24, wherein the total time the eye contact devices engage said corneas is about three seconds.
Claim 28
Dependent Claim
62 words
A method as claimed in claim 20, wherein said characteristics include amplitudes and areas of the waveshapes derived from each eye, the amounts of distortion of the waveshapes derived from each eye, and the delay time of the waveshapes from each eye with respect to the corresponding ECG signal, wherein said amplitudes, areas, distortion and delay time serve to permit said inference.
Claim 29
Dependent Claim
168 words
Apparatus for noninvasively sensing ocular pulses of a mammal, which pulses serve as a basis for indicating presence of a disease or malfunctioning body part which causes alterations in the ocular pulses, that comprises: piezoelectric transducer means to receive simultaneously undamped ocular pulses from the two eyes of the mammal and operable to convert the ocular pulses to signals in the form of similar complex electric pulses whose individual shape corresponds identically to the corresponding shape of the undamped ocular pulses, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact elements positioned to engage simultaneously the respective corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact elements substantially horizontally into engagement with the respective corneas; and means connected to receive said signals and operable to permit derivation of information from which the presence of a disease or malfunctioning body part can be inferred.
Claim 30
Dependent Claim
168 words
Apparatus for noninvasively sensing ocular pulses of a mammal, which pulses serve as a basis for indicating presence of a disease or malfunctioning body part which causes alterations in the ocular pulses, that comprises: piezoelectric transducer means to receive simultaneously undamped ocular pulses from the two eyes of the mammal and operable to convert the ocular pulses to signals in the form of similar complex electric pulses whose individual shape corresponds identically to the corresponding shape of the undamped ocular pulses, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact elements positioned to engage simultaneously the respective corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact elements substantially horizontally into engagement with the respective corneas; and means connected to receive said signals and operable to permit derivation of information from which the presence of a disease or malfunctioning body part can be inferred.
Claim 31
Dependent Claim
26 words
Apparatus as claimed in claim 27, wherein the piezoelectric transducer means is also operative to produce signals corresponding to the intraocular pulse in both eyes simultaneously.
Claim 32
Dependent Claim
61 words
Apparatus as defined by claim 27, in which the disease or malfunctioning body part is a condition of glaucoma of said at least one eye, in which said means connected comprises display means operable to display said signals as a series of waveshapes, and in which said information is found in the shape of each waveshape, in said series of waveshapes.
Claim 33
Dependent Claim
186 words
Apparatus for noninvasively sensing ocular pulsations of a mammal, which pulsations serve as a basis for indicating presence of a disease or malfunctioning body part which causes alterations in the ocular pulses, said pulsations being complex waveforms that include, in the healthy mammal, a dicrotic notch, that comprises: piezoelectric transducer means to receive simultaneously undamped ocular pulsations from the two eyes of the mammal and operable to convert the ocular pulsations to signals in the form of similar complex electric pulses whose individual shape corresponds identically to the corresponding shape of the ocular pulsations and including said dicrotic notch, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact elements positioned to engage simultaneously the respective corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact elements substantially horizontally into engagement with the respective corneas; and means connected to receive said signals and operable to permit derivation of information from which the presence of a disease or malfunctioning body part can be inferred.
Claim 34
Dependent Claim
186 words
Apparatus for noninvasively sensing ocular pulsations of a mammal, which pulsations serve as a basis for indicating presence of a disease or malfunctioning body part which causes alterations in the ocular pulses, said pulsations being complex waveforms that include, in the healthy mammal, a dicrotic notch, that comprises: piezoelectric transducer means to receive simultaneously undamped ocular pulsations from the two eyes of the mammal and operable to convert the ocular pulsations to signals in the form of similar complex electric pulses whose individual shape corresponds identically to the corresponding shape of the ocular pulsations and including said dicrotic notch, said transducer means comprising a pair of simultaneously operative piezoelectric benders disposed to bend by substantially horizontal movement, having eye contact elements positioned to engage simultaneously the respective corneas of the two eyes disposed substantially vertically and having support means supporting said piezoelectric benders for movement of said eye contact elements substantially horizontally into engagement with the respective corneas; and means connected to receive said signals and operable to permit derivation of information from which the presence of a disease or malfunctioning body part can be inferred.
Claim 35
Dependent Claim
26 words
Apparatus as claimed in claim 30, wherein the piezoelectric transducer means is also operative to produce signals corresponding to the intraocular pulse in both eyes simultaneously.
Claim 36
Dependent Claim
42 words
Apparatus according to claim 30 in which the lasted-named means is operable to permit determination of peak-to-peak value of the dicrotic notch, area under the individual waveform, the anacrotic slope of the individual waveform and the catacrotic slope of the individual waveform.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-24 | 1989-08-26 | 1990-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-24 | 1993-08-26 | 1994-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-24 | 1997-08-26 | 1998-02-25 | $7700.00 | Window Closed / Lapsed |