US4579866A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
Assignee: USV Pharmaceutical Corp
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Filing: 1984-05-29
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Granted: 1986-04-01
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Expires: 2004-05-29
Abstract
Abstract Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein: R 1 and R 2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl-lower alkyl, aryl-lower alkoxy, halogenated aryl-lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl; A is H, aryl, lower alkyl, aryl-lower alkyl or heteroaryl; and B is ##STR2## n=0-6, wherein D is H, CONR 3 R 4 , CO 2 H, CO 2 R 5 , CH 2 OH or CH 2 OR 6 , wherein R 3 , R 4 , R 5 and R 6 are independently H, lower alkyl, aryl, aryl-lower alkyl or heteroaryl; E is H, OH, lower alkyl, aryl or heteroaryl; and F is ##STR3## wherein G is the same as R 1 and R 2 , useful for the treatment of allergy, asthma and inflammatory conditions.
Inventors
- 👤 David Stevenson
- 👤 Robert C. Liu
- 👤 Laurence L. Ho
- 👤 Howard Jones
- 👤 Stephen Coutts
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:27
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; A; A61; A61P; A61P11/00; A61P11/08; A61P29/00; A61P37/00; A61P37/08; A61P43/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
104 words
A compound of the molecular structure represented by the formula ##STR10## and pharmaceutically acceptable salts thereof, wherein R 1 is H, lower alkoxy, aryl-lower alkoxy, lower alkenoxy, lower alkynoxy, or halogen; R 2 is lower alkoxy, aryl-lower alkoxy, lower alkenoxy, or lower alkynoxy with the proviso that when R 1 is halogen, R 2 cannot be lower alkoxy or lower alkenoxy, and wherein aryl in aryl-lower alkoxy is phenyl or napthyl; A is H, or lower alkyl; and B is ##STR11## wherein D is CO 2 R 5 ; wherein R 5 is H, or lower alkyl; E is H, and F is ##STR12##
Claim 2
Dependent Claim
104 words
A compound of the molecular structure represented by the formula ##STR10## and pharmaceutically acceptable salts thereof, wherein R 1 is H, lower alkoxy, aryl-lower alkoxy, lower alkenoxy, lower alkynoxy, or halogen; R 2 is lower alkoxy, aryl-lower alkoxy, lower alkenoxy, or lower alkynoxy with the proviso that when R 1 is halogen, R 2 cannot be lower alkoxy or lower alkenoxy, and wherein aryl in aryl-lower alkoxy is phenyl or napthyl; A is H, or lower alkyl; and B is ##STR11## wherein D is CO 2 R 5 ; wherein R 5 is H, or lower alkyl; E is H, and F is ##STR12##
Claim 3
Dependent Claim
6 words
The compound of N-[3-chloro-4-propargyloxyphenylacetyl]-D-phenylalanine methyl ester.
Claim 4
Dependent Claim
6 words
The compound of N-[3-chloro-4-propargyloxyphenylacetyl]-D-phenylalanine methyl ester.
Claim 5
Dependent Claim
6 words
The compound of N-[4-benzyloxy-3-chlorophenylacetyl]-D-phenylalanine methyl ester.
Claim 6
Dependent Claim
6 words
The compound of N-[4-benzyloxy-3-chlorophenylacetyl]-D-phenylalanine methyl ester.
Claim 7
Dependent Claim
6 words
The compound of N-[3-chloro-4-phenylethyloxyphenylacetyl]-N-methyl-D-phenylalanine methyl ester.
Claim 8
Dependent Claim
6 words
The compound of N-[3-chloro-4-phenylethyloxyphenylacetyl]-N-methyl-D-phenylalanine methyl ester.
Claim 9
Dependent Claim
6 words
The compound of N-[3-chloro-4-phenylethyloxyphenylacetyl]-D-phenylalanine methyl ester.
Claim 10
Dependent Claim
6 words
The compound of N-[3-chloro-4-phenylethyloxyphenylacetyl]-D-phenylalanine methyl ester.
Claim 11
Dependent Claim
23 words
A pharmaceutical composition for the treatment of allergic conditions in a mammal comprising a compound of claim 1 in a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
23 words
A pharmaceutical composition for the treatment of inflammatory conditions in a mammal comprising a compound of claim 1 in a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-31 | 1989-09-30 | 1990-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-31 | 1993-09-30 | 1994-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-31 | 1997-09-30 | 1998-04-01 | $7700.00 | Window Closed / Lapsed |