US4585652A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electrochemical controlled release drug delivery system
Assignee: University of Minnesota System
•
Filing: 1984-11-19
•
Granted: 1986-04-29
•
Expires: 2004-11-19
Abstract
Abstract A method is disclosed for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising ionically binding the chemical to redox sites on a charged polymer and releasing the bound chemical into the medium by neutralizing the charge on the polymer.
Inventors
- 👤 Larry L. Miller
- 👤 Ronald L. Blankespoor
- 👤 Baruch Zinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0009; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/559; Y; Y10; Y10S; Y10S424/00; Y10S424/07
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
59 words
A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising: (a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites; (b) contacting said polymeric body with said physiological medium; and (c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body.
Claim 2
Independent Claim
59 words
A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising: (a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites; (b) contacting said polymeric body with said physiological medium; and (c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said polymeric body is conductive.
Claim 4
Dependent Claim
36 words
The method of claim 2 wherein the charged polymeric body comprises cationic sites and is employed to bind anionic chemicals which are released by employing a cathodic current to neutralize the charge on the polymeric body.
Claim 5
Dependent Claim
16 words
The method of claim 3 wherein the charged polymeric body comprises oxidized polypyrrole or oxidized poly(beta-methoxythiophene).
Claim 6
Dependent Claim
36 words
The method of claim 2 wherein the charged polymeric body comprises anionic sites and is employed to bind cationic chemicals which are released by employing an anodic current to neutralize the charge on the polymeric body.
Claim 7
Dependent Claim
19 words
The method of claim 5 wherein the charged polymeric body comprises a reduced polyacetylene or a reduced, modified polyquinone.
Claim 8
Dependent Claim
31 words
The method of claim 1 wherein an electrode comprising said polymeric body is employed to bind said chemical by charging said electrode in contact with a solution of said ionic chemical.
Claim 9
Dependent Claim
28 words
The method of claim 7 wherein the ionic chemical is intermittently released by neutralizing the charge on the polymeric body with a plurality of quantified pulses of current.
Claim 10
Dependent Claim
13 words
The method of claim 8 wherein said bound chemicals are released in vivo.
Claim 11
Dependent Claim
21 words
The method of claim 9 wherein said electrode is implanted in a patient's body cavity or attached to the patient's skin.
Claim 12
Dependent Claim
32 words
The method of claim 1 wherein said ionic bioactive chemical is the anion of a pharmaceutically-acceptable salt selected from the group consisting of phosphate, sulfate, bisulfite, carboxylate and acidic N--H group salts.
Claim 13
Dependent Claim
15 words
The method of claim 1 wherein said ionic bioactive chemical comprises a quaternary ammonium cation.
Claim 14
Dependent Claim
30 words
The method of claim 12 wherein said ionic bioactive chemical is the cation of a pharmaceutically-acceptable salt selected from the group consisting of thiazinium, pyridinium, pyrrolidinium, thiazolium and piperidinium salts.
Claim 15
Independent Claim
62 words
A system for the controlled release of a bioactive ionic chemical into a physiological medium comprising: (a) a working electrode comprising a charged conductive polymer; (b) a bioactive ionic chemical ionically bound to said electrode; and (c) means comprising a power supply of reversible polarity which is capable of charging or discharging said polymer by delivering an anodic or cathodic current thereto.
Claim 16
Independent Claim
62 words
A system for the controlled release of a bioactive ionic chemical into a physiological medium comprising: (a) a working electrode comprising a charged conductive polymer; (b) a bioactive ionic chemical ionically bound to said electrode; and (c) means comprising a power supply of reversible polarity which is capable of charging or discharging said polymer by delivering an anodic or cathodic current thereto.
Claim 17
Dependent Claim
20 words
The system of claim 14 wherein said electrode comprises a coating of said conductive polymer on an inert, conductive substrate.
Claim 18
Dependent Claim
14 words
The system of claim 14 wherein the electrode consists essentially of said conductive polymer.
Claim 19
Dependent Claim
14 words
The system of claim 14 wherein said polymer comprises a continuous, conjugated pi-electron network.
Claim 20
Dependent Claim
26 words
The system of claim 14 further comprising a variable resistor between said current supply means and said electrode effective to control the magnitude of the current.
Claim 21
Dependent Claim
38 words
The system of claim 14 wherein said current supply means comprises an electrode having sufficient electrochemical potential with respect to the working electrode to discharge the charged working electrode when both electrodes are contacted with a physiological medium.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |