US4585754A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilization of proteins and peptides by chemical binding with chondroitin
Assignee: Future Labs Inc
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Filing: 1984-12-06
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Granted: 1986-04-29
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Expires: 2004-12-06
Abstract
Abstract Peptides, polypeptides, proteins, proteinaceous hormones, and enzymes are modified by covalently bonding chondroitin thereto, whereby their stability toward in vivo degradation is increased.
Inventors
- 👤 Lorraine F. Meisner
- 👤 Michael R. Schinitsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:34
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0089; A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/446; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; C07; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C07K14/00; C07K14/435; C07K14/575; C07K14/62; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
42 words
In a method of administering biologically active peptides to enhance or achieve a desired physiological response known to be elicited by said peptide, the improvement which comprises administering said peptide in combination with chondroitin chemically bonded thereto to prolong the desired response.
Claim 2
Dependent Claim
42 words
In a method of administering biologically active peptides to enhance or achieve a desired physiological response known to be elicited by said peptide, the improvement which comprises administering said peptide in combination with chondroitin chemically bonded thereto to prolong the desired response.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said peptide is a protein.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said peptide is a proteinaceous hormone.
Claim 5
Dependent Claim
11 words
The method of claim 3 wherein said proteinaceous hormone is insulin.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein said peptide is an enzyme.
Claim 7
Dependent Claim
11 words
The method of claim 5 wherein said enzyme is superoxide dimutase.
Claim 8
Dependent Claim
10 words
The method of claim 1 wherein said chondroitin is chondroitin-4-sulfate.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein said chondroitin is chondroitin-6-sulfate.
Claim 10
Dependent Claim
19 words
The method of claim 1 wherein said chondroitin has a molecular weight between about 5,000 and about 100,000 daltons.
Claim 11
Independent Claim
41 words
A method for prolonging the desired physiological response known to be elicited upon administration of a biologically active peptide, which method comprising administering said peptide in a biologically active stabilized form consisting essentially of said peptide having chondroitin covalently bonded thereto.
Claim 12
Independent Claim
41 words
A method for prolonging the desired physiological response known to be elicited upon administration of a biologically active peptide, which method comprising administering said peptide in a biologically active stabilized form consisting essentially of said peptide having chondroitin covalently bonded thereto.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |