US4591585A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-alkyl-androsta-1,4-diene-3,17-diones their production and pharmaceutical preparations containing same
Assignee: Bayer Pharma AG
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Filing: 1984-06-18
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Granted: 1986-05-27
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Expires: 2004-06-18
Abstract
Abstract 1-Alkyl androsta-1,4-diene-3,17-diones of the formula <IMAGE> wherein R1 is a methyl, ethyl, hydroxymethyl, C1-C3-alkoxymethyl, or C1-C4-alkanoyloxymethyl group, R6 is a hydrogen atom or a methyl group, and R7 is a hydrogen atom or a methyl group in the 7 alpha - or 7 beta -position, are useful for fertility control and for the treatment of estrogen-triggered diseases.
Inventors
- 👤 Ulrich Kerb
- 👤 Gerhard Sauer
- 👤 Rudolf Wiechert
- 👤 David Henderson
- 👤 Yukishige Nishino
- 👤 Sybille Beier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:54
CPC Classifications
C; C07; C07J; C07J1/00; C07J1/0003; C07J1/0011; A; A61; A61P; A61P13/00; A61P13/02; A61P15/00; A61P35/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
41 words
1-Alkyl-androsta-1,4-diene-3,17-diones of the formula ##STR7## wherein R 1 is a methyl, ethyl, hydroxymethyl, C 1 -C 3 -alkoxymethyl or C 1 -C 4 -alkanoyloxymethyl; R 6 is a hydrogen atom or methyl; and R 7 is a hydrogen atom or methyl.
Claim 2
Dependent Claim
41 words
1-Alkyl-androsta-1,4-diene-3,17-diones of the formula ##STR7## wherein R 1 is a methyl, ethyl, hydroxymethyl, C 1 -C 3 -alkoxymethyl or C 1 -C 4 -alkanoyloxymethyl; R 6 is a hydrogen atom or methyl; and R 7 is a hydrogen atom or methyl.
Claim 3
Dependent Claim
6 words
1-Methylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 4
Dependent Claim
8 words
1,7α-Dimethylandrosta-1,4-diene-3,17-dione and 1,7β-dimethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 5
Dependent Claim
6 words
1,6α-Dimethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 6
Dependent Claim
6 words
1-Ethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 7
Dependent Claim
6 words
1-Acetoxymethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 8
Dependent Claim
6 words
1-Hydroxymethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 9
Dependent Claim
6 words
1-Ethoxymethylandrosta-1,4-diene-3,17-dione, a compound of claim 1.
Claim 10
Dependent Claim
16 words
A pharmaceutical composition comprising a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
10 words
A compound of claim 1, wherein R 1 is hydroxymethyl.
Claim 12
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is C 1-3 -alkoxymethyl.
Claim 13
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is C 1-4 -alkanoyloxymethyl.
Claim 14
Dependent Claim
14 words
A composition of claim 1, wherein the amount of said compound is 10-100 mg.
Claim 15
Dependent Claim
20 words
A method of inhibiting estrogen biosynthesis in a patient comprising administering an effective amount of a compound of claim 1.
Claim 16
Dependent Claim
20 words
A method of inhibiting aromatase activity in a patient comprising administering an effective amount of a compound of claim 1.
Claim 17
Dependent Claim
23 words
A method of treating an abnormally increased estrogen level in a patient comprising admixing an effective amount of a compound of claim 1.
Claim 18
Dependent Claim
21 words
A method of treating benign prostatic hyperplasia in a patient comprising administering an effective amount of a compound of claim 1.
References Cited (Backward Citations)
US4456600A
Cited
US4474701A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-26 | 1989-11-25 | 1990-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-26 | 1993-11-25 | 1994-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-26 | 1997-11-25 | 1998-05-27 | $7700.00 | Window Closed / Lapsed |