US4593073A
Expired / Lapsed
US
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Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
Assignee: Royal Institution for the Advancement of Learning
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Filing: 1985-04-23
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Granted: 1986-06-03
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Expires: 2005-04-23
Abstract
Abstract The invention is concerned with a novel polymer addition product comprising a hydrophilic polymer backbone having a molecular weight of at least about 5,000 and to which are attached amino acid containing pendants, the pendants containing at least one arginine or lysine amino acid. The polymeric compounds of the invention are highly efficient adsorbents for bilirubin and other bile pigments, as well as for bile acids such as cholic acid.
Inventors
- 👤 Leon E. St-Pierre
- 👤 G. Ronald Brown
- 👤 Dominique S. Henning
- 👤 Marlene Bouvier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:49
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/30; A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; C07; C07K; C07K17/00; C07K17/02; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
42 words
A polymer addition product comprising a hydrophilic polymer backbone having a molecular weight of at least about 5,000 and to which are chemically bonded amino acid containing pendants, said pendants containing at least one arginine or lysine amino acid in deprotected form.
Claim 2
Dependent Claim
42 words
A polymer addition product comprising a hydrophilic polymer backbone having a molecular weight of at least about 5,000 and to which are chemically bonded amino acid containing pendants, said pendants containing at least one arginine or lysine amino acid in deprotected form.
Claim 3
Dependent Claim
24 words
A polymer addition product as claimed in claim 1, wherein said polymer backbone has a molecular weight of from about 5,000 to about 2,000,000.
Claim 4
Dependent Claim
15 words
A polymer addition product as claimed in claim 1, wherein said polymer backbone is cross-linked.
Claim 5
Dependent Claim
108 words
A polymer addition product as claimed in claim 1, having the general formula: ○P --(A.sub.1).sub.m --(X).sub.n --(A.sub.2).sub.o --(Y).sub.p --(A.sub.3).sub.q (I) wherein: the symbol ○P -- represents the polymer backbone; A 1 , A 2 and A 3 are identical or different and each represent an amino acid or an oligo-peptidic chain; X and Y are identical or different and each represent Arg or Lys, or a sequence thereof; and m, n, o, p and q are, independently, 0 or 1; with the proviso that at least one of n and p is 1 and the total number of amino acids in any pendant does not exceed about 20.
Claim 6
Dependent Claim
41 words
A polymer addition product as claimed in claim 4, having the formula: Z.sub.r --Ala.sub.3 -- ○P (I') wherein ○P -- represents a water swellable polyamide resin, Z is Arg or Lys and r is an integer varying from 1 to 5.
Claim 7
Dependent Claim
25 words
A polymer addition product as claimed in claim 5, wherein said water swellable polyamide resin is a copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane.
Claim 8
Dependent Claim
31 words
A polymer addition product as claimed in claim 5, wherein ○P -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane, Z is Arg and n is 2.
Claim 9
Dependent Claim
31 words
A polymer addition product as claimed in claim 5, wherein ○P -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane, Z is Arg and n is 3.
Claim 10
Dependent Claim
31 words
A polymer addition product as claimed in claim 5, wherein ○P -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane, Z is Arg and n is 5.
Claim 11
Dependent Claim
31 words
A polymer addition product as claimed in claim 5, wherein ○P -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane, Z is Lys and n is 5.
Claim 12
Dependent Claim
32 words
A polymer addition product as claimed in claim 4, having the formula: His.sub.1 Arg.sub.2 Ala.sub.3 -- ○P wherein ○ -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane.
Claim 13
Dependent Claim
33 words
A polymer addition product as claimed in claim 4, having the formula: Arg.sub.1 Ala.sub.3 Arg.sub.1 Ala.sub.3 -- ○P wherein ○P -- represents a water swellable copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane.
Claim 14
Dependent Claim
30 words
A method of treating hyperbilirubinemia in an affected human, which comprises orally administering to said human an effective bilirubin-adsorbing amount of a polymer addition product as defined in claim 1.
Claim 15
Dependent Claim
44 words
A method as claimed in claim 13, wherein the polymer addition product has the formula: Z.sub.r --Ala.sub.3 -- ○P (I') wherein ○P -- represents a water swellable polyamide resin, Z is Arg or Lys and r is an integer varying from 1 to 5.
Claim 16
Dependent Claim
23 words
A method as claimed in claim 14, wherein the water swellable polyamide resin is a copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane.
Claim 17
Dependent Claim
38 words
A method of treating hyperbilirubinemia in an affected human by hemoperfusion, which comprises perfusing blood plasma from said human through a column packed with a bilirubin adsorbent consisting of a polymer addition product as defined in claim 1.
Claim 18
Dependent Claim
44 words
A method as claimed in claim 16, wherein the polymer addition product has the formula: Z.sub.r --Ala.sub.3 -- ○P (I') wherein ○P -- represents a water swellable polyamide resin, Z is Arg or Lys and r is an integer varying from 1 to 5.
Claim 19
Dependent Claim
23 words
A method as claimed in claim 17, wherein the water swellable polyamide resin is a copolymer of dimethylacrylamide and N-acryl-1,6-diaminohexane reticulated with bisacrylyldiaminoethane.
Claim 20
Dependent Claim
31 words
A method of reducing hypercholesteremia in an affected human, which comprises orally administering to said human an effective bile acid-adsorbing amount of a polymer addition product as defined in claim 1.
Claim 21
Dependent Claim
44 words
A method as claimed in claim 19, wherein the polymer addition product has the formula: Z.sub.r --Ala.sub.3 -- ○P (I') wherein ○P -- represents a water swellable polyamide resin, Z is Arg or Lys and r is an integer varying from 1 to 5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |