US4597965A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and composition for controlling corneal hydration
Assignee: Holles Laboratories Inc
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Filing: 1982-05-26
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Granted: 1986-07-01
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Expires: 2002-05-26
Abstract
Abstract An ophthalmic solution for treating corneal edema concurrent with epithelial discontinuity, healing epithelial defects, and protecting against epithelial trauma containing electrolytes at only isotonic levels but containing hydrophilic macromolecules at such concentration that their collodial osmotic pressure is equal or greater than the imbibition pressure of corneal stroma.
Inventors
- 👤 Frank J. Holly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
66 words
A method of corneal dehydration in a human or animal eye comprising applying thereto an effective cornea dehydrating amount of an aqueous solution of a hydrophilic nonviscous polyacrylamide having an average molecular weight of between about 40,000 and about 150,000, said polyacrylamide being present at a colloidal osmolality between about 40 and 200 torr and in a concentration of from about 5 to 25% by weight.
Claim 2
Independent Claim
66 words
A method of corneal dehydration in a human or animal eye comprising applying thereto an effective cornea dehydrating amount of an aqueous solution of a hydrophilic nonviscous polyacrylamide having an average molecular weight of between about 40,000 and about 150,000, said polyacrylamide being present at a colloidal osmolality between about 40 and 200 torr and in a concentration of from about 5 to 25% by weight.
Claim 3
Dependent Claim
17 words
The method of claim 1, in which said ophthalmic solution comprises, in addition, an eye compatible preservative.
Claim 4
Dependent Claim
12 words
The method of claim 2 in which said preservative is chlorhexidine digluconate.
Claim 5
Dependent Claim
17 words
The method of claim 1 in which said ophthalmic solution comprises, in addition, an eye compatible anesthetic.
Claim 6
Dependent Claim
11 words
The method of claim 4 in which said anesthetic is proparacaine.
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-30 | 1989-12-30 | 1990-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-30 | 1993-12-30 | 1994-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-30 | 1997-12-30 | 1998-07-01 | $7700.00 | Window Closed / Lapsed |