US4623661A
Expired / Lapsed
US
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Lipoxygenase inhibiting compounds
Assignee: Abbott Laboratories
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Filing: 1985-04-26
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Granted: 1986-11-18
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Expires: 2005-04-26
Abstract
Abstract Compounds of the formula ##STR1## where R 1 is a trinuclear aromatic or biaryl group; R 2 is hydrogen or C 1 to C 6 alkyl or cycloalkyl; n is 0 or 1; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12-, and 15-lipoxygenase.
Inventors
- 👤 James B. Summers, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61P; A61P11/00; A61P17/00; A61P29/00; A61P37/00; A61P37/08; A61P43/00; C; C07; C07C; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/24; C07C2603/26
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
39 words
A compound of the formula ##STR7## where R 1 is a trinuclear aromatic or biaryl group; R 2 is hydrogen or C 1 to C 6 alkyl or cycloalkyl; n is 1; and M is a pharmaceutically acceptable cation.
Claim 2
Dependent Claim
39 words
A compound of the formula ##STR7## where R 1 is a trinuclear aromatic or biaryl group; R 2 is hydrogen or C 1 to C 6 alkyl or cycloalkyl; n is 1; and M is a pharmaceutically acceptable cation.
Claim 3
Dependent Claim
16 words
A compound according to claim 1 wherein R 2 is C 1 to C 6 alkyl.
Claim 4
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is 3-biphenyl.
Claim 5
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is 4-(2,4,6-trimethylphenyl)-phenyl.
Claim 6
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is 3-phenanthryl.
Claim 7
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is 4-(1-naphthyl)phenyl.
Claim 8
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is 4-(2-naphthyl)phenyl.
Claim 9
Dependent Claim
36 words
A compound according to claim 1 wherein the pharmaceutically acceptable cation is a nontoxic cation selected from the group consisting of hydrogen, alkali metal cations, alkaline earth metal cations, and ammonium, quaternary ammonium and amine cations.
Claim 10
Dependent Claim
44 words
A method of inhibiting lipoxygenase activity in a human or lower animal host in need of such treatment, comprising administering to the human or lower animal host a compound according to claim 1 in an amount effective to inhibit lipoxygenase activity in the host.
Claim 11
Dependent Claim
15 words
A method according to claim 9 wherein the compound is administered orally, parenterally, or topically.
Claim 12
Dependent Claim
24 words
A method according to claim 10 wherein the compound is administered at a dosage of from 0.001 to 100 mg/kg body weight per day.
Claim 13
Dependent Claim
24 words
A method according to claim 11 wherein the compound is administered at a dosage of from 0.01 to 10 mg/kg body weight per day.
Claim 14
Dependent Claim
31 words
A composition in unit dosage form for the inhibition of lipoxygenase activity in a human or lower animal host, comprising a compound according to claim 1 and a pharmaceutical carrier material.
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US3681445A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-17 | 1990-05-19 | 1990-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-17 | 1994-05-19 | 1994-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-17 | 1998-05-19 | 1998-11-18 | $7700.00 | Window Closed / Lapsed |