US4631270A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
Assignee: Research Corp
•
Filing: 1985-03-25
•
Granted: 1986-12-23
•
Expires: 2005-03-25
Abstract
Abstract Therapeutically useful pseudopeptides characterized by the replacement of at least one peptide group, both in a naturally occurring peptide or protein by a thiomethylene group are useful in the treatment of various metabolic malfunctions.
Inventors
- 👤 John A. Yankeelov, Jr.
- 👤 Kam-Fook Fok
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:27
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/02; C07C; C07C271/00; C07C271/06; C07C271/08; C07C271/10; C07C271/22; C07C323/00; C07C51/00; C07D; C07D277/00; C07D277/02; C07D277/08; C07D277/12; C07D277/16; C07K5/00; C07K5/04; C07K5/06; C07K5/06104; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13; Y10S930/15
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
60 words
Pseudodipeptides useful in the preparation of peptide mimics of a member of the natural catalyst substrate pairs, said pseudodipeptides being selected from the group consisting of Gly Ψ Leu, Phe Ψ His, Gly Ψ Ile, Leu Ψ Leu, Ala Ψ Ala, Tyr Ψ Gly, Arg Ψ Gly, Pro Ψ Gly -NH 2 , Lys Ψ Ser, and Arg Ψ Met.
Claim 2
Dependent Claim
60 words
Pseudodipeptides useful in the preparation of peptide mimics of a member of the natural catalyst substrate pairs, said pseudodipeptides being selected from the group consisting of Gly Ψ Leu, Phe Ψ His, Gly Ψ Ile, Leu Ψ Leu, Ala Ψ Ala, Tyr Ψ Gly, Arg Ψ Gly, Pro Ψ Gly -NH 2 , Lys Ψ Ser, and Arg Ψ Met.
Claim 3
Dependent Claim
34 words
A pseudopeptide useful in the treatment of hypertension, selected from the group consisting of Leu Ψ Leu-Val-Tyr, Ac-Phe Ψ His-Leu-Leu-Val-Tyr-Ser-OH, Ac-Phe-His-Leu Ψ Leu-Val-Tyr-Ser-OH and Ac-Phe Ψ His-Leu Ψ Leu-Val-Tyr-Ser-OH and pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
34 words
A pseudopeptide useful in the treatment of hypertension, selected from the group consisting of Leu Ψ Leu-Val-Tyr, Ac-Phe Ψ His-Leu-Leu-Val-Tyr-Ser-OH, Ac-Phe-His-Leu Ψ Leu-Val-Tyr-Ser-OH and Ac-Phe Ψ His-Leu Ψ Leu-Val-Tyr-Ser-OH and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
45 words
A pseudopeptide useful in the treatment of corneal ulceration or rheumatoid arthritis selected from the group consisting of Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Gln-Arg-Gly-OEt;Ac-Pro-Gln-Gly Ψ Leu-Ala-Gly-Gln-Arg-Gly-OEt; Ac-Pro-Leu-Gly Ψ Ile-Ala-Gly-Leu-Arg-Gly-OEt; and Ac-Pro-Leu-Gly Ψ Leu-Ala-Gly-Leu-Arg-Gly-OEt; Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Gln Ψ Arg; Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Leu Ψ Arg, and pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
45 words
A pseudopeptide useful in the treatment of corneal ulceration or rheumatoid arthritis selected from the group consisting of Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Gln-Arg-Gly-OEt;Ac-Pro-Gln-Gly Ψ Leu-Ala-Gly-Gln-Arg-Gly-OEt; Ac-Pro-Leu-Gly Ψ Ile-Ala-Gly-Leu-Arg-Gly-OEt; and Ac-Pro-Leu-Gly Ψ Leu-Ala-Gly-Leu-Arg-Gly-OEt; Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Gln Ψ Arg; Ac-Pro-Gln-Gly Ψ Ile-Ala-Gly-Leu Ψ Arg, and pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
39 words
A pseudopetide useful in the treatment of LHRH-related endocrine disorders selected from the group consisting of: pGlu-His-Trp-Ser-Tyr Ψ Gly-Leu-Arg-Pro-Gly-NH 2 pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro Ψ Gly-NH 2 pGlu-His-Trp-Ser-Tyr Ψ Gly-Leu-Arg-Pro Ψ Gly-NH 2 PGlu-His-Trp-Ser-tyr-Gly Ψ Leu-Arg-Pro-Gly-NH 2 and pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
39 words
A pseudopetide useful in the treatment of LHRH-related endocrine disorders selected from the group consisting of: pGlu-His-Trp-Ser-Tyr Ψ Gly-Leu-Arg-Pro-Gly-NH 2 pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro Ψ Gly-NH 2 pGlu-His-Trp-Ser-Tyr Ψ Gly-Leu-Arg-Pro Ψ Gly-NH 2 PGlu-His-Trp-Ser-tyr-Gly Ψ Leu-Arg-Pro-Gly-NH 2 and pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
14 words
A pseudopeptide useful in the relief of pain having the formula Tyr Ψ Gly-Gly-Phe-Leu.
Claim 10
Dependent Claim
14 words
A pseudopeptide useful in the relief of pain having the formula Tyr Ψ Gly-Gly-Phe-Leu.
Claim 11
Dependent Claim
26 words
A pseudopeptide useful in the treatment of emphysema selected from the group consisting of Ac-Ala-Ala Ψ Ala Oet, Ac-Ala-Ala-Ala Ψ Ala-OEt, and pharmaceutically acceptable slats thereof.
Claim 12
Dependent Claim
26 words
A pseudopeptide useful in the treatment of emphysema selected from the group consisting of Ac-Ala-Ala Ψ Ala Oet, Ac-Ala-Ala-Ala Ψ Ala-OEt, and pharmaceutically acceptable slats thereof.
Claim 13
Dependent Claim
25 words
A pseudopeptide for the modulation of urokinase activity selected by from the group consisting Ac-Ser-Ile-Arg-Ψ Met-Arg-Asp-Val-OEt, Ac-Glu-Asn-Arg-Lys Ψ Ser -Ser-Ile-Ile-OEt and pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim
25 words
A pseudopeptide for the modulation of urokinase activity selected by from the group consisting Ac-Ser-Ile-Arg-Ψ Met-Arg-Asp-Val-OEt, Ac-Glu-Asn-Arg-Lys Ψ Ser -Ser-Ile-Ile-OEt and pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim
22 words
A method of treating hypertension in mammals which comprises administering to said mammal an effective amount of the pseudopeptide of claim 1.
Claim 16
Dependent Claim
26 words
A method of treating corneal ulceration or rheumatoid arthritis in mammals which comprises administering to said mammal an effective amount of the pseudopeptide of claim 2.
Claim 17
Dependent Claim
24 words
A method of treating LHRH-related endocrine disorders in mammals which comprises administering to said mammals an effective amount of a pseudopeptide of claim 3.
Claim 18
Dependent Claim
22 words
A method of relieving pain in mammals which comprises administering to said mammal as effective amount of a pseudopeptide of claim 4.
Claim 19
Dependent Claim
23 words
A method of treatment of emphysema in mammals which comprise administering to said mammal an effective amount of a pseudopeptide of claim 5.
Claim 20
Dependent Claim
24 words
A method for modulation of urokinase activity in mammals which comprises administering to said mammal an effection amount of a pseudopeptide of claim 6.
References Cited (Backward Citations)
US3973006A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-22 | 1990-06-23 | 1990-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-22 | 1994-06-23 | 1994-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-22 | 1998-06-23 | 1998-12-23 | $7700.00 | Window Closed / Lapsed |