US4642229A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone-seeking complexes of Technetium-99m
Assignee: GE Healthcare Ltd
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Filing: 1984-04-16
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Granted: 1987-02-10
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Expires: 2004-04-16
Abstract
Abstract A bone-seeking, Technetium-99m-ethylene glycol-1,2-bisphosphonate complex has been found to be useful as a bone-scanning agent. The complex, which is prepared by adding Technetium-99m, as an aqueous solution of pertechnetate, to a composition comprising a mixture of ethylene glycol-1,2-bisphosphonic acid or a non-toxic salt thereof with a reducing agent for pertechnetate, is taken up rapidly in bone to give scans of high definition and compares favorably in this and other respects to other bone-scanning agents.
Inventors
- 👤 Stephen A. Cumming
- 👤 James D. Kelly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:33
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K51/0489; C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/386; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
34 words
A composition for use in the preparation of a Technetium-99m bone scanning agent comprising a mixture of ethylene glycol-1,2-bisphosphonic acid or a non-toxic salt thereof together with a non-toxic reducing agent for pertechnetate ions.
Claim 2
Dependent Claim
34 words
A composition for use in the preparation of a Technetium-99m bone scanning agent comprising a mixture of ethylene glycol-1,2-bisphosphonic acid or a non-toxic salt thereof together with a non-toxic reducing agent for pertechnetate ions.
Claim 3
Dependent Claim
23 words
The composition as claimed in claim 1, wherein the reducing agent is a non-toxic salt of tin (2+), iron (2+) or chromium (2+).
Claim 4
Dependent Claim
16 words
The composition as claimed in claim 2, wherein the reducing agent is a non-toxic stannous salt.
Claim 5
Dependent Claim
26 words
The composition as claimed in claim 2, wherein the ethylene glycol-1,2-bisphosphonic acid or non-toxic salt thereof is present in a molar excess over the reducing agent.
Claim 6
Dependent Claim
16 words
A bone-seeking composition comprising an aqueous solution of a complex of Technetium-99m and ethylene glycol-1,2-bisphosphonic acid.
Claim 7
Dependent Claim
16 words
A bone-seeking composition comprising an aqueous solution of a complex of Technetium-99m and ethylene glycol-1,2-bisphosphonic acid.
Claim 8
Dependent Claim
12 words
A bone-seeking composition comprising an aqueous solution of a Technetium-99-m-tin-ethylene glycol-1,2,-bisphosphonate complex.
Claim 9
Dependent Claim
12 words
A bone-seeking composition comprising an aqueous solution of a Technetium-99-m-tin-ethylene glycol-1,2,-bisphosphonate complex.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |