7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease

Claim 1

A compound having the structure ##STR105## including all stereoisomers thereof, wherein m is 0 to 4; A is --CH═CH-- or --CH 2 --CH 2 --; n is 1 to 5; Q is --CH═CH--, --CH 2 --, ##STR106## or a single bond; R is CO 2 H, CO 2 alkyl, CO 2 alkali metal, CO 2 polyhydroxyamine salt, --CH 2 OH, ##STR107## wherein R 4 and R 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl at least one of R 4 and R 5 being other than hydroxy and lower alkoxy; p is 1 to 4; R 1 is H or lower alkyl; q is 1 to 12; R 2 is H or lower alkyl; and R 3 is H, lower alkyl, lower alkenyl containing 2 to 12 carbons, lower alkynyl containing 2 to 12 carbons, aryl, arylalkyl, lower alkoxy, arylalkoxy, aryloxy, amino, alkylamino, arylamino, arylalkylamino, ##STR108## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl, or arylalkoxyalkyl; (CH 2 ) m , (CH 2 ) n and (CH 2 ) p may be unsubstituted or substituted with 1 or 2 lower alkyl groups and/or 1 or 2 halogens; (CH 2 ) q may be unsubstituted or substituted by 1 or 2 halo, hydroxy, alkoxy, amine, alkylamine, arylamine, amide, thioamide, thiol, alkylthio, arylthio, cyano, or nitro groups; amide refers to ##STR109## wherein R 6 and R 7 are independently hydrogen, lower alkyl or aryl; wherein lower alkyl or alkyl alone or as part of another group contains 1 to 12 carbons and is unsubstituted or is substituted with halo, CF 3 , alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl, alkylcycloalkyl, hydroxy, alkylamino, alkanoylamino, arylcarbonylamino, nitro, cyano, thiol or alkylthio; aryl alone or as part of another group contains 6 to 10 carbons in the ring portion and is unsubstituted or is substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens, 1 or 2 alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylcarbonylamino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups; cycloalkyl alone or as part of another group contains 3 to 12 carbons and is unsubstituted or is substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups, 1 or 2 lower alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylcarbonylamino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups; and alkanoyl refers to lower alkyl linked to a carbonyl group.