US4670424A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
Assignee: Merck and Co Inc
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Filing: 1983-09-19
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Granted: 1987-06-02
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Expires: 2003-09-19
Abstract
Abstract A compound of the formula R-CH2-O-W and its pharmaceutically acceptable salts wherein R is a purine, a substituted purine, a pyrimidine or a substituted pyrimidine, wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thiol or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbon atoms; and W is <IMAGE> The compounds have antiviral activity.
Inventors
- 👤 Malcolm MacCoss
- 👤 Richard Tolman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:32
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6564; C07F9/6571; C07F9/6574; C07F9/65746; A; A61; A61P; A61P31/00; A61P31/12; C07F9/6561; C07F9/65616
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
61 words
A compound of the formula R--CH 2 --O--W and its pharmaceutically acceptable salts wherein R is a purine, a substituted purine, a pyrimidine or a substituted pyrimidine, wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thiol or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbon atoms; and W is ##STR6##
Claim 2
Dependent Claim
61 words
A compound of the formula R--CH 2 --O--W and its pharmaceutically acceptable salts wherein R is a purine, a substituted purine, a pyrimidine or a substituted pyrimidine, wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thiol or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbon atoms; and W is ##STR6##
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein W is ##STR7##
Claim 4
Dependent Claim
10 words
A compound according to claim 1, wherein W is ##STR8##
Claim 5
Dependent Claim
28 words
A compound according to claim 1, wherein the purine or substituted purine is attached at its 9-position and the pyrimidine or substituted pyrimidine is attached at its 1-position.
Claim 6
Dependent Claim
26 words
A compound according to claim 1, wherein the substituted purine, is a mono- or disubstituted purine and the substituted pyrimidine is a di- or trisubstituted pyrimidine.
Claim 7
Dependent Claim
17 words
A compound according to claim 1, wherein R is guanine, adenine, 2,6-diaminopurine, cytosine, thymine, uracil or 5-fluorouracil.
Claim 8
Dependent Claim
17 words
A compound according to claim 2, wherein R is guanine, adenine, 2,6-diaminopurine, cytosine, thymine, uracil or 5-fluorouracil.
Claim 9
Dependent Claim
17 words
A compound according to claim 3, wherein R is guanine, adenine, 2,6-diaminopurine, cytosine, thymine, uracil or 5-fluorouracil.
Claim 10
Dependent Claim
7 words
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine cyclic pyrophosphate, according to claim 1.
Claim 11
Dependent Claim
7 words
9-[(1,3-Dihydroxy-2-propoxy)methyl]adenine cyclic pyrophosphate, according to claim 1.
Claim 12
Dependent Claim
7 words
1-[1,3-Dihydroxy-2-propoxymethyl]uracil cyclic pyrophosphate, according to claim 1.
Claim 13
Dependent Claim
7 words
9-[(2,3-Dihydroxy-1-propoxy)methyl]guanine cyclic pyrophosphate according to claim 1.
Claim 14
Dependent Claim
19 words
A anti-viral pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
29 words
A method of treating herpes type virus infection in mammals comprising administering to a patient in need of such treatment an effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-01 | 1990-12-01 | 1991-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-01 | 1994-12-01 | 1995-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-01 | 1998-12-01 | 1999-06-02 | $7700.00 | Window Closed / Lapsed |