US4716147A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic airial peptides
Assignee: Monsanto Co
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Filing: 1986-03-27
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Granted: 1987-12-29
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Expires: 2006-03-27
Abstract
Abstract Novel synthetic atrial peptides are provided with enhanced natriuretic properties by substituting one or two arginine residues for the N-terminal ser-ser in atriopeptins I, II and III and their physiologically acceptable salts, esters and amides.
Inventors
- 👤 Foe S. Tjoeng
- 👤 Kam F. Fok
- 👤 Steven P. Adams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:27
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/58; C07K14/582; A; A61; A61P; A61P7/00; A61P7/10; C07K14/60; A61K; A61K38/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
40 words
A synthetic peptide having potent natriuretic activity comprising the following amino acid sequence: R.sub.1 -cys-phe-gly-gly-arg-X-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R.sub.2 wherein R 1 =arg, arg-arg, leu-arg-arg, ser-leu-arg-arg, D-arg, D-arg-D-arg, R 2 =ser-phe, ser-phe-arg, ser-phe-arg-tyr, X=met, ile, or the physiologically acceptable salts, esters or amides thereof.
Claim 2
Dependent Claim
40 words
A synthetic peptide having potent natriuretic activity comprising the following amino acid sequence: R.sub.1 -cys-phe-gly-gly-arg-X-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R.sub.2 wherein R 1 =arg, arg-arg, leu-arg-arg, ser-leu-arg-arg, D-arg, D-arg-D-arg, R 2 =ser-phe, ser-phe-arg, ser-phe-arg-tyr, X=met, ile, or the physiologically acceptable salts, esters or amides thereof.
Claim 3
Dependent Claim
18 words
A peptide of claim 1 in the oxidized form having a disulfide bond between the two cysteine residues.
Claim 4
Dependent Claim
17 words
A peptide of claim 1 in which the amide is a mono- or di-lower alkyl substituted amide.
Claim 5
Dependent Claim
10 words
A peptide of claim 1 in which X is ile.
Claim 6
Dependent Claim
10 words
A peptide of claim 2 in which X is ile.
Claim 7
Dependent Claim
11 words
A peptide of claim 5 in which R 2 is ser-phe-arg-tyr.
Claim 8
Dependent Claim
15 words
A peptide of claim 5 in which R 2 is ser-phe-arg in the amide form.
Claim 9
Dependent Claim
11 words
A peptide of claim 3 in which the amide is ethylamide.
Claim 10
Dependent Claim
11 words
A peptide of claim 7 in which the amide is ethylamide.
Claim 11
Dependent Claim
11 words
A peptide of claim 1 in which R 1 is arg.
Claim 12
Dependent Claim
11 words
A peptide of claim 1 in which R 1 is arg-arg.
Claim 13
Dependent Claim
11 words
A peptide of claim 2 in which R 1 is arg.
Claim 14
Dependent Claim
11 words
A peptide of claim 2 in which R 1 is arg-arg.
Claim 15
Dependent Claim
15 words
A peptide of claim 11 in which R 2 is ser-phe-arg in the amide form.
Claim 16
Dependent Claim
11 words
A peptide of claim 14 in which the amide is ethylamide.
Claim 17
Dependent Claim
33 words
A method for producing natriuresis, diuresis, vasodilation or change in renal blood flow in a mammal comprising administering to said mammal a therapeutically effective amount of a peptide as defined in claim 1.
References Cited (Backward Citations)
US4496544A
Cited
US4508712A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-28 | 1991-06-29 | 1991-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-28 | 1995-06-29 | 1995-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-28 | 1999-06-29 | 1999-12-29 | $7700.00 | Window Closed / Lapsed |