US4717727A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments for the inhibition of proline hydroxylase and lysine hydroxylase
Assignee: Hoechst AG
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Filing: 1985-08-29
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Granted: 1988-01-05
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Expires: 2005-08-29
Abstract
Abstract Esters of pyridine-2,4- and -2,5-dicarboxylic acid act as inhibitors of proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants, in particular for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of Cl q .
Inventors
- 👤 Volkmar Gunzler
- 👤 Hartmut Hanauske-Abel
- 👤 Jurgen Mohr
- 👤 Georg Tschank
- 👤 Kari Kivirikko
- 👤 Kari Majamaa
- 👤 Dietrich Brocks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:04
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; A; A61; A61P; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07D213/80
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
92 words
A pharmaceutical preparation for inhibiting proline hydroxylase and lysine hydroxylase and for use as a fibrosuppressant and immunosuppressant which comprises an effective inhibiting or suppressing amount of a compound of the formula I ##STR2## in which R 1 and R 2 , which are identical or different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring and a tolerated pharmaceutical vehicle.
Claim 2
Dependent Claim
92 words
A pharmaceutical preparation for inhibiting proline hydroxylase and lysine hydroxylase and for use as a fibrosuppressant and immunosuppressant which comprises an effective inhibiting or suppressing amount of a compound of the formula I ##STR2## in which R 1 and R 2 , which are identical or different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring and a tolerated pharmaceutical vehicle.
Claim 3
Dependent Claim
18 words
A preparation as claimed in claim 1, in which both R 1 and R 2 are said alkyl.
Claim 4
Dependent Claim
22 words
A preparation as claimed in claim 2, in which R 1 and R 2 are alkyl of 1 to 3 carbon atoms.
Claim 5
Dependent Claim
16 words
A preparation as claimed in claim 3, in which R 1 and R 2 are ethyl.
Claim 6
Dependent Claim
16 words
A preparation as claimed in claim 3, in which R 1 and R 2 are methyl.
Claim 7
Independent Claim
105 words
A method for affecting the metabolism of collagen and collagen-like substances and the biosynthesis of C1 q which comprises administering to a patient suffering from disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of C1 q an effective amount of a compound of the formula I ##STR3## in which R 1 and R 2 , which are identical or different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring.
Claim 8
Independent Claim
105 words
A method for affecting the metabolism of collagen and collagen-like substances and the biosynthesis of C1 q which comprises administering to a patient suffering from disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of C1 q an effective amount of a compound of the formula I ##STR3## in which R 1 and R 2 , which are identical or different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring.
Claim 9
Dependent Claim
22 words
A method as claimed in claim 6, wherein in the compound of formula I R 1 and R 2 are said alkyl.
Claim 10
Dependent Claim
16 words
A method as claimed in claim 7, wherein said alkyl has 1 to 3 carbon atoms.
Claim 11
Dependent Claim
15 words
A method as claimed in claim 7, wherein R 1 and R 2 are ethyl.
Claim 12
Dependent Claim
15 words
A method as claimed in claim 7, wherein R 1 and R 2 are methyl.
Claim 13
Independent Claim
101 words
A method for inhibiting proline hydroxylase and lysine hydroxylase and for treatment with a fibrosuppressant or immunosuppressant which comprises administering to a patient in need of such treatment an effective inhibiting or suppressing amount of a compound of the formula I ##STR4## in which R 1 and R 2 , which are identical and different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring, together with a tolerated pharmaceutical vehicle.
Claim 14
Independent Claim
101 words
A method for inhibiting proline hydroxylase and lysine hydroxylase and for treatment with a fibrosuppressant or immunosuppressant which comprises administering to a patient in need of such treatment an effective inhibiting or suppressing amount of a compound of the formula I ##STR4## in which R 1 and R 2 , which are identical and different, both are alkyl of 1 to 6 carbon atoms, or one of R 1 and R 2 is hydrogen and the other said alkyl, the group R 2 OCO being bonded in the 4- or 5-position of the pyridine ring, together with a tolerated pharmaceutical vehicle.
Claim 15
Dependent Claim
21 words
A method as claimed in claim 11, in which both R 1 and R 2 of said compounds are said alkyl.
Claim 16
Dependent Claim
23 words
A method as claimed in claim 12, in which both R 1 and R 2 are alkyl of 1 to 3 carbon atoms.
Claim 17
Dependent Claim
16 words
A method as claimed in claim 13, in which R 1 and R 2 are ethyl.
Claim 18
Dependent Claim
16 words
A method as claimed in claim 13, in which R 1 and R 2 are methyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-04 | 1991-07-06 | 1992-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-04 | 1995-07-06 | 1996-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-04 | 1999-07-06 | 2000-01-05 | $7700.00 | Window Closed / Lapsed |