US4737140A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Irradiation chamber for photoactivation patient treatment system
Assignee: Janssen Pharmaceuticals Inc
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Filing: 1987-05-22
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Granted: 1988-04-12
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Expires: 2007-05-22
Abstract
Abstract A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.
Inventors
- 👤 Kyu H. Lee
- 👤 Vernon H. Troutner
- 👤 Jack Goss
- 👤 Martin J. King
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:30
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3681; A61M1/3616; A61M1/3621; A61M1/3622; A61M1/36225; A61M1/36226; A61M1/362261; A61M1/362262; A61M1/3683; A61M1/3693; A61M1/3696; A61M1/36222; A61M1/36224; A61M1/362266; A61M2205/00; A61M2205/05; A61M2205/051; A61M2209/00; A61M2209/08; A61M2209/082; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
141 words
A flat plate irradiation chamber, for use in a patient treatment system for altering cells, including treating the cells with a photoactivatable agent and passing the cells and the agent through a field of photoactivating radiation whereby said agent is caused to be activated and to affect said cells, said agent and said cells being contained in the irradiation chamber during irradiation, said flat plate irradiation chamber comprising: a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a rigid serpentine pathway for conducting said cells through said field of radiation; and pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said cells to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.
Claim 2
Dependent Claim
141 words
A flat plate irradiation chamber, for use in a patient treatment system for altering cells, including treating the cells with a photoactivatable agent and passing the cells and the agent through a field of photoactivating radiation whereby said agent is caused to be activated and to affect said cells, said agent and said cells being contained in the irradiation chamber during irradiation, said flat plate irradiation chamber comprising: a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a rigid serpentine pathway for conducting said cells through said field of radiation; and pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said cells to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.
Claim 3
Dependent Claim
19 words
The chamber of claim 1 wherein at least one of said sheets is substantially transparent to said photoactivating radiation.
Claim 4
Dependent Claim
31 words
The chamber of claim 2 which further comprises means for preventing creeping movement of said tubing means during rotation of said peristaltic pump when said pump block means is engaged therewith.
Claim 5
Dependent Claim
21 words
The chamber of claim 2 further comprising memory means for providing information characteristic of said chamber to said patient treatment system.
Claim 6
Dependent Claim
27 words
The chamber as described in claim 4 further comprising sensor probe means in thermal communication with said fluid for providing an output in response to fluid temperature.
Claim 7
Dependent Claim
27 words
The chamber of claim 4 further comprising means for receiving urging force from said patient treatment system for engaging said pump block means with said peristaltic pump.
Claim 8
Dependent Claim
32 words
The chamber of claim 4 wherein said memory means is selected from the group consisting of integrated circuit having a non-volatile memory, integrated circuit having a power source, and magnetic memory means.
Claim 9
Dependent Claim
135 words
An irradiation chamber for use in a system for treating blood, comprising: a serpentine portion comprising two flat, closely spaced apart rigid plates having walls therebetween defining a rigid serpentine pathway between the plates, having an inlet and an outlet, said outlet in flow communication with flexible tubing; and a pump block, integral with said serpentine portion for containing said tubing, comprising a pump track along which is emplaced said tubing for pumping engagement with a pump when said irradiation chamber is inserted into said system; whereby said irradiation chamber may be inserted into said system without the need for a separate step to establish flow communication between the inlet of said serpentine chamber and said flexible tubing and wherein said irradiation chamber may be removed from the system together with all blood contacting elements.
Claim 10
Dependent Claim
135 words
An irradiation chamber for use in a system for treating blood, comprising: a serpentine portion comprising two flat, closely spaced apart rigid plates having walls therebetween defining a rigid serpentine pathway between the plates, having an inlet and an outlet, said outlet in flow communication with flexible tubing; and a pump block, integral with said serpentine portion for containing said tubing, comprising a pump track along which is emplaced said tubing for pumping engagement with a pump when said irradiation chamber is inserted into said system; whereby said irradiation chamber may be inserted into said system without the need for a separate step to establish flow communication between the inlet of said serpentine chamber and said flexible tubing and wherein said irradiation chamber may be removed from the system together with all blood contacting elements.
Claim 11
Dependent Claim
30 words
The chamber of claim 1, wherein the cells are presented to the irradiation in a serpentine pathway having a large surface area to volume ratio thereby reducing cellular self-shielding effects.
Claim 12
Dependent Claim
23 words
The chamber of claim 1, wherein the top and bottom sheets are male and female thin plate sections bonded together in sealing arrangement.
Claim 13
Dependent Claim
17 words
The chamber of claim 1, wherein the pump block is molded as part of the serpentine pathway.
Claim 14
Dependent Claim
16 words
The chamber of claim 1, wherein the pump block is separately mounted to the serpentine pathway.
Claim 15
Dependent Claim
20 words
The chamber of claim 1, wherein after mating, the distance between the top and bottom sheets is about 0.04 inches.
Claim 16
Dependent Claim
11 words
The chamber of claim 1, wherein the rigid plates are polycarbonate.
Claim 17
Dependent Claim
101 words
In combination, a system for treating blood and an irradiation chamber for use therein, wherein: said system comprises a pump, means for treating blood and means for receiving the chamber; and said chamber comprises a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a serpentine pathway for conducting said blood; and pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said blood to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.
Claim 18
Dependent Claim
101 words
In combination, a system for treating blood and an irradiation chamber for use therein, wherein: said system comprises a pump, means for treating blood and means for receiving the chamber; and said chamber comprises a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a serpentine pathway for conducting said blood; and pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said blood to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.
Claim 19
Dependent Claim
20 words
The combination of claim 15, wherein the blood in the serpentine pathway has a large surface area to volume ratio.
Claim 20
Dependent Claim
26 words
The combination of claim 15, wherein the top and bottom sheets of the chamber are male and female thin, plate sections bonded together in sealing arrangement.
Claim 21
Dependent Claim
20 words
The combination of claim 15, wherein the distance between the top and bottom sheets after mating is about 0.04 inches.
Claim 22
Dependent Claim
11 words
The combination of claim 15, wherein the rigid sheets are polycarbonate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-12 | 1991-10-12 | 1992-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-12 | 1995-10-12 | 1996-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-12 | 1999-10-12 | 2000-04-12 | $7700.00 | Window Closed / Lapsed |